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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 46 - 54 (9page)
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Purpose The aim of this study is to identify the prognostic factors of distant metastasis (DM) afterinduction chemotherapy (IC) followed by concurrent chemoradiotherapy (CRT) for locoregionallyadvanced head and neck cancer (HNC).
Materials and MethodsA total of 321 patients with HNC who underwent IC followed by CRT treated between January2005 and December 2010 were analyzed retrospectively. IC consisted of three courses ofdocetaxel (70 mg/m2) and cisplatin (75 mg/m2) every three weeks, followed by radiotherapyof 66-70 Gy/2 Gy per fraction/5 fractions per week concurrent with weekly cisplatin (40mg/m2). Tumor/nodal stage, primary site, tumor differentiation, lower neck node involvement(level IV, VB, and supraclavicular regions), number of concurrent chemotherapy cycles,overall duration of radiotherapy, and response to IC were assessed as potential prognosticfactors influencing DM and survival outcome.
ResultsThe five-year loco-regional recurrence and DM rates were 23.6% and 18.2%. N stage, overallduration of radiotherapy, lower neck node involvement, and response to IC were significantfactors for DM. With a median follow-up period of 52 months (range, 4 to 83 months), the5-year progression-free, DM-free, and overall survival rates were 41.2%, 50.7%, and 55.1%,respectively. Lower neck node involvement (p=0.008) and poor response to IC (p < 0.001)showed an association with significantly inferior DM-free survival.
ConclusionEven with the addition of IC, the DM rate and survival outcome were poor when metastaticlower neck lymph nodes were present or when patients failed to respond after receiving IC.
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참고문헌 (22)
참고문헌 신청
Adelstein DJ / 2003 / An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamou
Alvi A / 1997 / Development of distant metastasis after treatment of advanced-stage head and neck cancer / Head Neck 19 : 500 ~ 505
Bhide SA / 2008 / Sequential induction chemotherapy followed by radical chemo-radiation in the treatment of locoregionally advanced head-and-neck cancer / Br J Cancer 99 : 5
Cohen EE / 2012 / DeCIDE: a phase III randomized trial of docetaxel (D), cisplatin (P), 5-fluorouracil (F) (TPF) induction chemotherapy (IC) in patients with N2/N3 locally ad
Edge SB / 2009 / AJCC cancer staging manual / Springer
Alvi A / 1997 / Development of distant metastasis after treatment of advanced-stage head and neck cancer / Head Neck 19 : 500 ~ 505
Bhide SA / 2008 / Sequential induction chemotherapy followed by radical chemo-radiation in the treatment of locoregionally advanced head-and-neck cancer / Br J Cancer 99 : 5
Cohen EE / 2012 / DeCIDE: a phase III randomized trial of docetaxel (D), cisplatin (P), 5-fluorouracil (F) (TPF) induction chemotherapy (IC) in patients with N2/N3 locally ad
Edge SB / 2009 / AJCC cancer staging manual / Springer
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