지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제9권 제4호
- 발행연도
- 2016.12
- 수록면
- 374 - 381 (8page)
- DOI
- http://dx.doi.org/10.21053/ceo.2015.01683
이용수
초록· 키워드
오류제보하기
Objectives. Induction chemotherapy (IC) is likely to be effective for biologically distinct subgroups of oral cancer and biomarker development may lead to identification of those patients.
Methods. We evaluated immune cell infiltration, stroma formation and structure of the invasive front as well as the immunohistochemical expression of alpha smooth muscle actin (ASMA), CD163, E-cadherin, N-cadherin, and the laminin gamma 2 chain in pretreatment biopsy specimens and surgical resections after IC in 20 patients with locally advanced oral cancer who were treated in a prospective, ongoing, phase II trial on IC using docetaxel, cisplatin, and 5-fluorouracil (TPF).
Results. Significant negative prognostic factors for incomplete pathological tumor response to IC were alcohol abuse (P=0.032), cN+ (P=0.042), and <30% tumor reduction after first cycle of IC (P=0.034). Of the investigated histological parameters and biomarkers only a low membrane-bound expression of E-cadherin showed a trend to be associated with incomplete response to IC (P=0.061). Low expression of ASMA in stromal vessels and a strong tumor invasion front were significantly associated to tumor recurrence (P=0.024 and P=0.004, respectively). The median follow-up of all patients was 35 months. Alcohol abuse (P<0.001), <30% tumor reduction after first cycle of IC (P=0.005), and a strong tumor invasion front (P=0.019) were negative prognostic factors for overall survival.
Conclusion. A strong predictive biomarker among the investigated parameters for benefitting from TPF IC could not be found. The extent of the tumor invasion front was a negative prognostic marker for recurrence and survival in oral cancer treated by TPF IC followed by surgery and postoperative radiochemotherapy.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Argiris A / 2013 / Current status and future directions in induction chemotherapy for head and neck cancer / Crit Rev Oncol Hematol 88(1):57~74
Posner MR. / 2007 / Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer / N Engl J Med 357(17):1705~1715
Vermorken JB. / 2007 / Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer / N Engl J Med 357(17):1695~1704
Haddad R. / 2013 / Induction chemotherapy followed by concurrent chemoradiotherapy(sequential chemoradiotherapy)versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer(PARADIGM) : a randomised phase 3 trial / Lancet Oncol 14(3):257~264
Cohen EE. / 2014 / Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer / J Clin Oncol 32(25):2735~2743
Posner MR. / 2007 / Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer / N Engl J Med 357(17):1705~1715
Vermorken JB. / 2007 / Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer / N Engl J Med 357(17):1695~1704
Haddad R. / 2013 / Induction chemotherapy followed by concurrent chemoradiotherapy(sequential chemoradiotherapy)versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer(PARADIGM) : a randomised phase 3 trial / Lancet Oncol 14(3):257~264
Cohen EE. / 2014 / Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer / J Clin Oncol 32(25):2735~2743
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