농촌 지역 주민의 혈청 ferritin 수준과 대사증후군과의 관련성

류소연; Ryu; 김기순; 박종; 강명근; 한미아

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자료유형: 학술저널

저자정보: 류소연 Ryu 김기순 박종 강명근 한미아

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제41권 제2호

발행연도: 2008.1

수록면: 115 - 120 (6page)

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the relationship between serum ferritin and the metabolic syndrome (MS). Methods : We conducted a cross-sectional study of 1,444 adults over age 40 and under age 70 that lived in a rural area and participated in a survey conducted as part of the Korean Rural Genomic Cohort Study (KRGCS). The MS was defined as the presence of at least three of the followings: elevated blood pressure, low high density lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, or abdominal obesity. After adjustment for age, alcohol intake, menopausal status, body mass index (BMI), high sensitivity C-reactive protein (hs-CRP), and alanine aminotransferase (ALT), odds ratios (ORs) for the prevalence of the MS by sex were calculated for quartiles of serum ferritin using logistic regression analysis. Results : The MS was more common in those persons with the highest levels of serum ferritin, compared to persons with the lowest levels, in men (37.1% vs. 22.4%, p=0.006) and women (58.8% vs. 34.8, p<0.001). In both sexes, the greater the number of MS components presents, the greater the serum ferritin levels. After adjustment for age, alcohol intake, and menopausal status, the OR for metabolic syndrome, comparing the fourth quartile of ferritin with the first quartile, was 2.21 (95% confidence interval ; CI=1.26-3.87; p-trend=0.024) in men and 2.10 (95% CI=1.40-3.17; p-trend=0.001) in women. However, after further adjustment for BMI, hs-CRP, and ALT, the ORs were statistically attenuated in both sexes. Conclusions : Moderately elevated serum ferritin levels were not independently associated with the prevalence of the MS after adjusting for other risk factors. Further studies are needed to obtain evidence concerning the association between serum ferritin levels and the MS.

#Cross-sectional study #Ferritin #Iron #Metabolic syndrome

참고문헌 (23)

참고문헌 신청

Andrews, N.C. / 1999 / Disorders of iron metabolism / N Engl J Med 341 (26) : 1986 ~ 1995

Cho, Y.S. / 2005 / Association of serum ferritin and abdominal obesity and insulin resistance / J Korean Soc Study Obes 14 (2) : 76 ~ 81

Choi, K.M. / 2005 / Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal women / Metabolism 54 (11) : 1510 ~ 15

Fernandez-Real, J.M. / 1998 / Serum ferritin as a component of the insulin resistance syndrome / Diabetes Care 21 (1) : 62 ~ 68

Ferrannini, E. / 2000 / Insulin resistance, iron and liver / Lancet 355 (9222) : 2181 ~ 2182

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