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논문 기본 정보

자료유형
학술저널
저자정보
Gyu Sang Yoo (Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of Medicine) Jeong Il Yu (Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of Medicine) Hee Chul Park (Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of Medicine)
저널정보
소화기인터벤션의학회 International Journal of Gastrointestinal Intervention International Journal of Gastrointestinal Intervention 제10권 제4호
발행연도
2021.10
수록면
175 - 182 (8page)
DOI
10.18528/ijgii210043

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Hepatocellular carcinoma (HCC) is the most common primary liver cancer, the sixth most common cancer, and the fourth leading cause of cancerrelated deaths worldwide. There are curative local treatment options for HCC, including liver transplantation, surgical resection, and radiofrequency ablation, all of which are applicable for a few patients. For advanced HCC, systemic treatments, such as target agents or immunotherapies, are recommended, however, with unsatisfactory efficacy. Therefore, radiation therapy (RT) has been used as an alternative or combination therapy. With the advances of RT technique in image guidance and accurate beam delivery, its applications have increased for the management of HCC. Proton beam therapy (PBT) is a highly advanced RT technique. Since proton beams have unique physical properties with a finite range in the distal direction, PBT has the potential to escalate the radiation dose without a significant increase in the risk of complications compared with X-ray therapy in the treatment of HCC. Various studies have reported favorable oncological outcomes and toxicity risks of PBT for HCC patients. In this review, we discuss the physical and biological properties, technical issues, current clinical data, and future perspectives on PBT for the treatment of HCC patients.

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