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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,203 - 1,213 (11page)
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Purpose This study aimed to explore the functions and mechanisms of C-C motif chemokine receptor 6 (CCR6), a gene associated with progression and metastasis of colorectal cancer (CRC), in radiosensitivity of rectal cancer (RC). Materials and Methods RNA sequencing and immunohistochemical analysis on CCR6 expression were performed in pretreatment tissues of RC patients exhibiting different therapeutic effects of radiotherapy. Colonogenic survival assay was conducted in different CRC cell lines to assess their radiosensitivity. And the impact of CCR6 expression on radiosensitivity was validated through RNA interference. The DNA damage repair (DDR) abilities of cell lines with different CCR6 expression were evaluated through immunofluorescence-based H2AX quantification. Results The CCR6 mRNA level was higher in patients without pathologic complete remission (pCR) than in those with pCR (fold changed, 2.11; p=0.004). High-level expression of CCR6 protein was more common in the bad responders than in the good responders (76.3% vs. 37.5%, p < 0.001). The CRC cell lines with higher CCR6 expression (LoVo and sw480) appeared to be more radioresistant, compared with the sw620 cell line which had lower CCR6 expression. CCR6 knockdown made the LoVo cells more sensitive to ionizing radiation (sensitization enhancement ratio, 1.738; p < 0.001), and decreased their DDR efficiency. Conclusion CCR6 might affect the RC radiosensitivity through DDR process. These findings supported CCR6 as a predicting biomarker of radiosensitivity and a potential target of radiosensitization for RC patients.
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참고문헌 (30)
참고문헌 신청
Chen W / 2016 / Cancer statistics in China, 2015 / CA Cancer J Clin 66:115~132
박혜진 / 2018 / Patterns of Rectal Cancer Radiotherapy Adopting Evidence-Based Medicine: An Analysis of the National Database from 2005 to 2016 / Cancer Research and Treatment 50(3):975~983
Fokas E / 2014 / Tumor regression grading after preoperative chemoradiotherapy for locally advanced rectal carcinoma revisited: updated results of the CAO/ARO/AIO-94 trial / J Clin Oncol 32:1554~1562
Trakarnsanga A / 2014 / Comparison of tumor regression grade systems for locally advanced rectal cancer after multimodality treatment / J Natl Cancer Inst 106:dju248
Morgan MA / 2015 / Molecular pathways: overcoming radiation resistance by targeting DNA damage response pathways / Clin Cancer Res 21:2898~2904
박혜진 / 2018 / Patterns of Rectal Cancer Radiotherapy Adopting Evidence-Based Medicine: An Analysis of the National Database from 2005 to 2016 / Cancer Research and Treatment 50(3):975~983
Fokas E / 2014 / Tumor regression grading after preoperative chemoradiotherapy for locally advanced rectal carcinoma revisited: updated results of the CAO/ARO/AIO-94 trial / J Clin Oncol 32:1554~1562
Trakarnsanga A / 2014 / Comparison of tumor regression grade systems for locally advanced rectal cancer after multimodality treatment / J Natl Cancer Inst 106:dju248
Morgan MA / 2015 / Molecular pathways: overcoming radiation resistance by targeting DNA damage response pathways / Clin Cancer Res 21:2898~2904
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