지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 154 - 160 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: cDNA microarray provided a powerful alternative,
with an unprecedented view scope, in monitoring
gene expression levels, and led to the discovery
of regulatory pathways involved in complicated biological
processes. This study w as performed to gain
better understanding of the molecular mechanisms
underlying the carcinogenesis and progression of
lung cancer.
Materials and Methods: Using a cDNA microarray,
representing 4,600 cDNA clusters, we studied the expression
profiles in 10 non-small cell lung cancer (NSCLC)
samples and the adjacent noncancerous lung tissues
form the same patients. The alterations in the levels
of gene expression were confirmed by reverse-transcription
PCR in 10 randomly selected genes.
Results: Genes that were differently expressed in the
cancerous and noncancerous tissues were identified.
One hundred and nine genes (of which 68 were known)
and 69 cDNAs (of which 32 were known) were up- and
down-regulated in ＞70% of the NSCLC samples, respectively.
In the cancerous tissues, the genes related to
the cell cycle, metabolism, cell structure and signal
transduction, were mostly up-regulated. Furthermore,
we identified a few putative tumor suppressor genes
that had previously been proposed by other workers.
Conclusions: These results provide, not only a new
molecular basis for understanding the biological properties
of NSCLC, but also useful resources for the
future development of diagnostic markers and therapeutic
targets for NSCLC. (Cancer Res Treat. 2003;35:154-160)
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Gene Expression Profile and Its Interpretation in Squamous Cell Lung Cancer
Molecular & cellular toxicology
2006 .01
-
cDNA Microarray Analysis of the Gene Expression after Ad5CMV-p16INK4a Gene Transfer in the Non-Small Cell Lung Cancer Cells
대한약학회 학술대회
2001 .01
-
cDNA Microarray Analysis of Gene Expression Profiles Associated with Cervical Cancer
Cancer Research and Treatment
2003 .01
-
신세포암종에서 cDNA Microarray를 이용한 유전자 발현에 관한 연구 - Decorin 발현의 임상병리학적 분석
Journal of Pathology and Translational Medicine
2003 .01
-
Profiling of Gene Expression According to Cancer Stage in Clear Cell Type of Renal Cell Carcinoma
Molecular & cellular toxicology
2005 .01
-
cDNA microarray analysis of gene expression based on Sasang
대한동의병리학회 학술대회논문집
2003 .07
-
cDNA Microarray Analysis of Differential Gene Expression in Gastric Cancer Cells Sensitive and Resistant to 5-Fluorouracil and Cisplatin
Cancer Research and Treatment
2005 .01
-
Genome-wide profiling induced by ionizing radiation (IR) in non-small cell lung cancer (NSCLC) grown as three-dimensional spheroid
Molecular & cellular toxicology
2010 .01
-
RADIOACTIVE cDNA MICROARRAY (II): GENE EXPRESSION PROFILING OF ANTIDEPRESSANT TREATMENT BY HUMAN cDNA MICROARRAY
대한핵의학회 학술대회
2003 .01
-
Biological Effects of Smoking-induced Environmental Toxicity
Molecular & cellular toxicology
2006 .01
-
Identification and characterization of a novel cancer/testis antigen gene
대한약학회 학술대회
2002 .01
-
Expression of potassium channel genes predicts clinical outcome in lung cancer
The Korean Journal of Physiology & Pharmacology
2019 .01
-
폐암세포주에서 아데노바이러스 매개 p16 유전자 전달로 인한 유전자 발현의 변화
Toxicological Research
2004 .06
-
폐암세포주에서 아데노바이러스 매개 p16 유전자 전달로 인한 유전자 발현의 변화
Toxicological Research
2004 .03
-
O1igonucleotide Microarray와 cDNA Microarray를 이용한 위암조직의 대단위 유전자 발현 비교
약학회지
2007 .01
-
Comparison of As2O3 and As4O6 in the Detection of SiHa Cervical Cancer Cell Growth Inhibition Pathway
Cancer Research and Treatment
2004 .01
-
Differentially Expressed Genes in Metastatic Advanced Egyptian Bladder Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Comparison of the Gene Expression Profiles Between Smokers With and Without Lung Cancer Using RNA-Seq
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray
Cancer Research and Treatment
2004 .01
-
Differential Protein and Gene Expression after Adenovirus-Mediated p16 Gene Transfer in Human Non-Small Cell Lung Cancer Cells
대한약학회 학술대회
2002 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0