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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제6호
- 발행연도
- 2019.1
- 수록면
- 529 - 537 (9page)
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초록· 키워드
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Lung cancer is the most common cause of cancer deaths worldwide and several molecular signatures have been developed to predict survival in lung cancer. Increasing evidence suggests that proliferation and migration to promote tumor growth are associated with dysregulated ion channel expression. In this study, by analyzing high-throughput gene expression data, we identify the differentially expressed K+ channel genes in lung cancer. In total, we prioritize ten dysregulated K+ channel genes (5 up-regulated and 5 down-regulated genes, which were designated as K-10) in lung tumor tissue compared with normal tissue. A risk scoring system combined with the K-10 signature accurately predicts clinical outcome in lung cancer, which is independent of standard clinical and pathological prognostic factors including patient age, lymph node involvement, tumor size, and tumor grade. We further indicate that the K-10 potentially predicts clinical outcome in breast and colon cancers. Molecular signature discovered through K+ gene expression profiling may serve as a novel biomarker to assess the risk in lung cancer.
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참고문헌 (63)
참고문헌 신청
Thorneloe KS / 2005 / Ion channels in smooth muscle : regulators of intracellular calcium and contractility / Can J Physiol Pharmacol 83:215~242
Krasznai Z / 2005 / Ion channels in T cells : from molecular pharmacology to therapy / Arch Immunol Ther Exp(Warsz) 53:127~135
Mason WT / 1988 / Control of secretion in anterior pituitary cells--linking ion channels, messengers and exocytosis / J Exp Biol 139:287~316
Baker EH / 2000 / Ion channels and the control of blood pressure / Br J Clin Pharmacol 49:185~198
Jentsch TJ / 2004 / Ion channels : function unravelled by dysfunction / Nat Cell Biol 6:1039~1047
Krasznai Z / 2005 / Ion channels in T cells : from molecular pharmacology to therapy / Arch Immunol Ther Exp(Warsz) 53:127~135
Mason WT / 1988 / Control of secretion in anterior pituitary cells--linking ion channels, messengers and exocytosis / J Exp Biol 139:287~316
Baker EH / 2000 / Ion channels and the control of blood pressure / Br J Clin Pharmacol 49:185~198
Jentsch TJ / 2004 / Ion channels : function unravelled by dysfunction / Nat Cell Biol 6:1039~1047
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