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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 59 - 65 (7page)
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초록· 키워드
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Purpose: Retinoic acid (RA) has been known to inhibit
the proliferation, and to induce apoptosis, of various
cancer cell lines. We investigated the correlation between
the protein levels of the RAR and RXR receptor families,
IGFBP-3 and AFP, and the RA sensitivity in hepatoma cell
lines.
Materials and Methods: The cell growth inhibition was
examined by assaying various 1 to 10μM RA treated
hepatoma cell lines. Western blot analysis for the RAR
and RXR families, AFP and IGFBP-3 were performed after
treatment with 10μM RA.
Results: The 1 to 10μM RA treatment induced growth
inhibition in the SNU368, SNU354, SNU398 and HepG2
cells. The cell growth of SNU449 and Hep3B were not
suppressed by 1μM, but were slightly suppressed by 10
μM RA. An increased expression of IGFBP-3 in HepG2,
SNU354, SNU398 and SNU368 cells, and a decreased expression
of α-fetoprotein (AFP), was observed from the
western blot analysis in all hepatoma cells tested, whereas
no confirmed tendency of RAR expressions was seen.
Conclusion: Our result showed that the growth inhibition
of RA differed according to the sensitivity of the
type of cells to RA. We supposed that RA-induced cell
growth inhibition may be related to the expressions of
IGFBP-3 and AFP, but no exact correlation exists between
the growth inhibition and receptor expression status in
hepatoma cell lines. (Cancer Rese Treat. 2003;35:59-65)
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