Throat Carriage Rate and Antimicrobial Resistance of Streptococcus pyogenes In Rural Children in Argentina

Gaston Delpech; Monica Sparo; Beatriz Baldaccini; Gisela Pourcel; Sabina Lissarrague; Leonardo Garcia Allende

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자료유형: 학술저널

저자정보: Gaston Delpech Monica Sparo Beatriz Baldaccini Gisela Pourcel Sabina Lissarrague Leonardo Garcia Allende

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제50권 제2호

발행연도: 2017.1

수록면: 127 - 132 (6page)

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Objectives: The aim of this study was to determine the prevalence of asymptomatic carriers of group A β-hemolytic streptococci (GAS) in children living in a rural community and to investigate the association between episodes of acute pharyngitis and carrier status. Methods: Throat swabs were collected from September to November 2013 among children 5-13 years of age from a rural community (Maria Ignacia-Vela, Argentina). The phenotypic characterization of isolates was performed by conventional tests. Antimicrobial susceptibility was assayed for penicillin, tetracycline, chloramphenicol, erythromycin, and clindamycin (disk diffusion). The minimum inhibitory concentration was determined for penicillin, cefotaxime, tetracycline, and erythromycin. Results: The carriage of β-hemolytic streptococci was detected in 18.1% of participants, with Streptococcus pyogenes in 18 participants followed by S. dysgalactiae ssp. equisimilis in 5. The highest proportion of GAS was found in 8 to 10-year-old children. No significant association between the number of episodes of acute pharyngitis suffered in the last year and the carrier state was detected (p>0.05). Tetracycline resistance (55.5%) and macrolide-resistant phenotypes (11.1%) were observed. Resistance to penicillin, cefotaxime, or chloramphenicol was not expressed in any streptococcal isolate. Conclusions: The present study demonstrated significant throat carriage of GAS and the presence of group C streptococci (S. dysgalactiae ssp. equisimilis) in an Argentinian rural population. These results point out the need for continuous surveillance of GAS and non-GAS carriage as well as of antimicrobial resistance in highly susceptible populations, such as school-aged rural children. An extended surveillance program including school-aged children from different cities should be considered to estimate the prevalence of GAS carriage in Argentina.

#Streptococcus pyogenes #Prevalence #Pharyngitis #Rural population #Argentina

참고문헌 (20)

참고문헌 신청

Ayer V / 2007 / Tetracycline resistance in group a streptococci: emergence on a global scale and influence on multiple-drug resistance / Antimicrob Agents Chemother 51 (5) :

Benouda A / 2009 / Place of Streptococcus pyogenes in the throat infection in Morocco and overview of its susceptibility to antibiotics / Pathol Biol (Paris) 57 (1) : 76 ~ 8

Bingen E / 2004 / Emergence of macrolide-resistant Streptococcus pyogenes strains in French children / Antimicrob Agents Chemother 48 (9) : 3559 ~ 3562

Carapetis JR / 2005 / The global burden of group A streptococcal diseases / Lancet Infect Dis 5 (11) : 685 ~ 694

Clinical and Laboratory Standards Institute / / M100-S23: performance standards for antimicrobial susceptibility testing; twenty-third informational supplement

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