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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 57 - 61 (5page)
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Background: The present analysis focuses on phenotypic and genotypic characterizations of efflux-mediated erythromycin resistance in Streptococcus pneumoniae due to an increase in macrolide resistance in S. pneumoniae worldwide.
Methods: We investigated the prevalence of efflux-mediated erythromycin resistance and its relevant genetic elements from 186 specimens of S. pneumonia isolated from clinical and normal flora from Tehran, Iran. The presence of erythromycin resistance genes was tested by PCR with two sets of primers, specific for erm(B) and mef(A/E), and their genetic elements with tetM, xis, and int genes. Isolates were typed with the BOX PCR method and tested for resistance to six antibiotics.
Results: Antibiotic susceptibility tests revealed that 100% and 47% isolates were resistant to tetracycline and erythromycin, respectively. The erythromycin and clindamycin double-disc diffusion test for macrolide-lincosamide-streptograminB (MLSB) resistance phenotype showed 74 (84%) isolates with the constitutive MLSB phenotype and the remaining with the M phenotype. BOX PCR demonstrated the presence of 7 types in pneumococci with the M phenotype. Fourteen (16%) isolates with the M phenotype harbored mef(A/E), tetM, xis, and int genes.
Conclusion: The present results suggest dissemination of polyclonal groups of S. pneumoniae with the M phenotype carrying resistance genes attributed to transposon 2009.
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참고문헌 (22)
참고문헌 신청
Henderson KL / 2010 / Reduction in erythromycin resistance in invasive pneumococci from young children in England and Wales / J Antimicrob Chemother 65:369~370
J J, M T N / 2013 / Prevalence of macrolide resistance and in vitro activities of six antimicrobial agents against clinical isolates of Streptococcus pneumoniae from a multi-center surveillance in Malaysia / Med J Malaysia 68:119~124
Xu X / 2010 / Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates / Antimicrob Agents Chemother 54:1152~1159
Pihlajamäki M / 2002 / Ribosomal mutations in Streptococcus pneumoniae clinical isolates / Antimicrob Agents Chemother 46:654~658
Taha N / 2012 / Genotypes and serotype distribution of macrolide resistant invasive and non-invasive Streptococcus pneumoniae isolates from Lebanon / Ann Clin Microbiol Antimicrob 11:2
J J, M T N / 2013 / Prevalence of macrolide resistance and in vitro activities of six antimicrobial agents against clinical isolates of Streptococcus pneumoniae from a multi-center surveillance in Malaysia / Med J Malaysia 68:119~124
Xu X / 2010 / Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates / Antimicrob Agents Chemother 54:1152~1159
Pihlajamäki M / 2002 / Ribosomal mutations in Streptococcus pneumoniae clinical isolates / Antimicrob Agents Chemother 46:654~658
Taha N / 2012 / Genotypes and serotype distribution of macrolide resistant invasive and non-invasive Streptococcus pneumoniae isolates from Lebanon / Ann Clin Microbiol Antimicrob 11:2
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