Differential Association of Vitamin D Deficiency With Albuminuria by Sex in the Korean General Population: A Cross-sectional Study of the Korea National Health and Nutrition Examination Survey 2011-2012

전용우; 신재용; 지종현; 조영대; 박은철

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자료유형: 학술저널

저자정보: 전용우 신재용 지종현 조영대 박은철

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제51권 제2호

발행연도: 2018.1

수록면: 92 - 99 (8page)

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Objectives: Albuminuria has emerged as a biomarker for several medical conditions, and vitamin D has received attention due to its associations with various disorders. We evaluated the association between low serum vitamin D levels and prevalent albuminuria by sex in the Korean general population. Methods: We analyzed 9823 participants (4401 males, 5422 females) from the Korea National Health and Nutrition Examination Survey 2011-2012 (KNHANES V-2), and categorized them as having a normal range of vitamin D levels, vitamin D insufficiency, or vitamin D deficiency. A multivariable logistic regression model was used to compare the risk of albuminuria across these groups. Stratified analyses were conducted by smoking status, obesity, and renal function. Results: Albuminuria was found in 325 of the 4401 male participants (7.4%) and in 455 of the 5422 female participants (8.4%). Among the males, vitamin D deficiency was associated with an odds ratio (OR) for albuminuria of 1.78 (95% confidence interval [CI], 1.07 to 2.97, p<0.05). However, such an association was not found in females. The association was stronger in male current smokers (OR, 3.54; 95% CI, 1.47 to 8.50; p=0.005). Conclusions: The findings of this study suggest that sex differences exist in the association between serum vitamin D deficiency and albuminuria. Additionally, we observed that the association was stronger in current smokers than in the overall male population, but was not seen in non-smokers. Therefore, different approaches by sex and smoking status might be needed when considering using vitamin D as a biomarker for renal function.

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참고문헌 신청

Hillege HL / 2002 / Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population / Circulation 106(14):1777~1782

장미애 / 2015 / Differences in Factors Associated with Albuminuria according to Gender and Comorbidities of Hypertension and Diabetes / Korean Journal of Family Medicine 36(6):316~322

Won JC / 2013 / Prevalence of and factors associated with albuminuria in the Korean adult population: the 2011 Korea National Health and Nutrition Examination Survey / PLoS One 8(12):e83273

Giovannucci E / 2008 / 25-Hydroxyvitamin D and risk of myocardial infarction in men: a prospective study / Arch Intern Med 168(11):1174~1180

Nam GE / 2014 / 25-Hydroxyvitamin D insufficiency is associated with cardiometabolic risk in Korean adolescents: the 2008-2009 Korea National Health and Nutrition Examination Survey (KNHANES) / Public Health Nutr 17(1):186~194

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