일개 농촌지역 노인의 아포지단백 E 다형성과 인지기능 변화

김상규; 황태윤; 이경수; 강복수; 조희순; 배영경

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자료유형: 학술저널

저자정보: 김상규 황태윤 이경수 강복수 조희순 배영경

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제42권 제4호

발행연도: 2009.1

수록면: 261 - 266 (6page)

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Objectives : The aim of this study is to examine the cognitive function change related to aging, the incidence of cognitive impairment, and the association between apolipoprotein E polymorphism and cognitive impairment through a follow-up of the elderly with normal cognitive ability at baseline. Methods : Two hundred and fifteen subjects aged 65 and over were surveyed in February, 1998 (baseline survey), and their cognitive function was assessed again in 2003 (1st follow-up) and the once again in 2006 (2nd follow-up). Ninety one subjects completed all surveys up through the 2nd follow-up and their cognitive function scores using MMSE-K (Korean Version of the Mini-Mental State Examination) and the distribution of apolipoprotein E allele were analyzed. Results : The cognitive function scores decreased with aging and the difference between baseline and the 2nd follow-up scores of the study increased with the age group. The incidence rate of cognitive impairment through an 8- year follow-up was 38.5% and higher in older age groups. Age was the only significant factor for incidence of cognitive impairment, but there was no significant association between apolipoprotein E genotype and incidence of cognitive impairment. Conclusions : The cognition of the elderly decreased with aging and the association of apolipoprotein E genotype with incidence of cognitive impairment was not significant in this study. To confirm the association between apolipoprotein E polymorphism and incidence of cognitive impairment further studies will be needed.

#Apolipoprotein E #Polymorphism #Aging #Cognition

참고문헌 (27)

참고문헌 신청

Auyeung TW / 2008 / Functional decline in cogni

Horejsi B / 2000 / Apolipoproteins and atherosclerosis. Apolipoprotein E and apolipoprotein(a) as candidate genes of premature development of atherosclerosis / Physiol Res 4

Johansson B / 1997 / Early cognitive markers of the incidence of dementia and mortality: A longitudinal population-based study of the oldest old / Int J Geriatr Psychiatry 12

Jonker C / 1998 / Association between apolipoprotein E epsilon4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia / Arch

Jorm A / 1987 / The Prevalence of dementia: A quantitative integration of the literature / Acta Psychiatr Scand 76 (5) : 465 ~ 479

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