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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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To identify a solution for the restricted availability of healthy lungs and the high risk of immune rejections following organ transplantation, tissue engineering techniques for culturing lungs have been studied by many research groups. The most promising method for culturing lungs is the utilization of a bio-scaffold that was prepared using harvested organs from human donors or other animals by removing their original cells. In this study, a pulsatile perfusion pump was used to alleviate the cell removal effect with the high fluid-dynamic power of the perfusion stream during the decellularization process, while other conventional studies focused on chemical methods to identify efficient detergents. The purpose of this study was to analyze the developed device by using energy equivalent pressure (EEP), which is an indicator of pulsatility, to understand the characteristics of pulsatile energy transmitted according to the load size by using the artificial model and compare it with the measured EEP. The pulsatility of the device can be estimated with the concept of fluid-dynamic energy during a particular constant time period or fluiddynamic power represented as EEP and EEP increment. Because the measured EEP of perfusion flow during decellularization can be changed by the amount of fluid leakage and the degree of clogging in the capillary vessels, EEP should be measured to determine whether the decellularization is progressing without problems. The decrement of EEP caused by the high perfusion resistance was observed from some experimental results that were obtained with artificial models. EEP can be used to monitor the decellularization process after analyzing the varying EEP according to the amount of load. It was confirmed that the EEP was maintained at a high level in the experiment using the harvested lungs from 12-13-week-old rats. In addition, it was confirmed that the cell removal time was faster than when continuous perfusion was performed. In this study, pulsatile power delivered to the lungs was measured to monitor the process of cell removal, and it serve as the evidence for efficient decellularization.
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참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)
/ / 2015 장기이식 통계연보 / 보건복지부·질병관리본부 장기이식관리센터
Alhamdani MS / 2010 / Single-step procedure for the isolation of proteins at near-native conditions from mammalian tissue for proteomic analysis on antibody microarrays / J
Baloa, L. A / 2001 / Elastance-based control of a mock circulatory system / Annals of biomedical engineering 29 (Issue 3) : 244 ~ 251
Brian Cox / 2006 / Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics / Nature protocols 1 : 1872 ~ 1878
/ / 2015 장기이식 통계연보 / 보건복지부·질병관리본부 장기이식관리센터
Alhamdani MS / 2010 / Single-step procedure for the isolation of proteins at near-native conditions from mammalian tissue for proteomic analysis on antibody microarrays / J
Baloa, L. A / 2001 / Elastance-based control of a mock circulatory system / Annals of biomedical engineering 29 (Issue 3) : 244 ~ 251
Brian Cox / 2006 / Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics / Nature protocols 1 : 1872 ~ 1878
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