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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 111 - 117 (7page)
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초록· 키워드
오류제보하기
Background: The impact of HLA and KIR ligand mismatching on the outcome of hematopoietic stem cell transplantation (HSCT) remains unclear. Previous reports have identified considerable ethnic differences in the impact of HLA and KIR ligand mismatches, as well as KIR ligand status, on HSCT; however, to date, no data has been acquired in Korean adult patients.
Methods: We investigated the association of high-resolution HLA matching on five loci (HLA-A, -B, -C, -DRB1, and -DQB1), KIR ligand mismatching, and KIR ligand status on the outcome of allogeneic HSCT from unrelated donors in 154 Korean adult patients treated at Seoul National University Hospital.
Results: In a multivariate analysis, less than 9/10 allelic matches in five HLA loci was an independent risk factor for acute graft-versus-host disease (GVHD) (grade II to IV) (P=0.019, odds ratio [OR]=2.7). In addition, HLA-A allele mismatching was increasingly prevalent in patients with acute GVHD compared to patients without (61.9% vs. 34.5%, P=0.06). For KIR ligand status, the patient and donor combination of both C1/C1 ligands showed better event-free and overall survival than combinations with C2 ligand patients or donors (P=0.048, P=0.034, respectively) by log-rank test.
Conclusions: Korean adult transplant patients with less than 9 of 10 HLA allele matches in the HLA-A, -B, -C, -DRB1, and DQB1 loci have a higher likelihood of developing acute GVHD (grade II to IV). Impact of KIR ligand status on clinical outcome should be further studied in a larger patient population.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Farag SS / 2002 / Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect / Blood 100 : 1935 ~ 1947
Fischer JC / 2007 / Relevance of C1 and C2 epitopes for hemopoietic stem cell transplantation: role for sequential acquisition of HLA-C-specific inhibitory killer Ig-like re
Fischer JC / 2012 / The impact of HLA-C matching depends on the C1/C2 KIR ligand status in unrelated hematopoietic stem cell transplantation / Immunogenetics 64 : 879 ~ 885
Gagne K / 2009 / Donor KIR3DL1/3DS1 gene and recipient Bw4 KIR ligand as progn
Giebel S / 2003 / Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors / Blood 102 : 814 ~ 819
Fischer JC / 2007 / Relevance of C1 and C2 epitopes for hemopoietic stem cell transplantation: role for sequential acquisition of HLA-C-specific inhibitory killer Ig-like re
Fischer JC / 2012 / The impact of HLA-C matching depends on the C1/C2 KIR ligand status in unrelated hematopoietic stem cell transplantation / Immunogenetics 64 : 879 ~ 885
Gagne K / 2009 / Donor KIR3DL1/3DS1 gene and recipient Bw4 KIR ligand as progn
Giebel S / 2003 / Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors / Blood 102 : 814 ~ 819
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