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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제6호
- 발행연도
- 2021.10
- 수록면
- 565 - 574 (10page)
- DOI
- 10.4196/kjpp.2021.25.6.565
이용수
초록· 키워드
오류제보하기
Astrocytes are activated in response to brain damage. Here, we found that expression of Kir4.1, a major potassium channel in astrocytes, is increased in activated astrocytes in the injured brain together with upregulation of the neural stem cell markers, Sox2 and Nestin. Expression of Kir4.1 was also increased together with that of Nestin and Sox2 in neurospheres formed from dissociated P7 mouse brains.
Using the Kir4.1 blocker BaCl2 to determine whether Kir4.1 is involved in acquisition of stemness, we found that inhibition of Kir4.1 activity caused a concentration-dependent increase in sphere size and Sox2 levels, but had little effect on Nestin levels.
Moreover, induction of differentiation of cultured neural stem cells by withdrawing epidermal growth factor and fibroblast growth factor from the culture medium caused a sharp initial increase in Kir4.1 expression followed by a decrease, whereas Sox2 and Nestin levels continuously decreased. Inhibition of Kir4.1 had no effect on expression levels of Sox2 or Nestin, or the astrocyte and neuron markers glial fibrillary acidic protein and β-tubulin III, respectively. Taken together, these results indicate that Kir4.1 may control gain of stemness but not differentiation of stem cells.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Kofuji P / 2000 / Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina / J Neurosci 20:5733~5740
Poopalasundaram S / 2000 / Glial heterogeneity in expression of the inwardly rectifying K+channel, Kir4.1, in adult rat CNS / Glia 30:362~372
Yakushigawa H / 1998 / A novel junction-like membrane complex in the optic nerve astrocyte of the Japanese macaque with a possible relation to a potassium ion channel / Anat Rec 250:465~474
Nagelhus EA / 2004 / Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1 / Neuroscience 129:905~913
Djukic B / 2007 / Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced shortterm synaptic potentiation / J Neurosci 27:11354~11365
Poopalasundaram S / 2000 / Glial heterogeneity in expression of the inwardly rectifying K+channel, Kir4.1, in adult rat CNS / Glia 30:362~372
Yakushigawa H / 1998 / A novel junction-like membrane complex in the optic nerve astrocyte of the Japanese macaque with a possible relation to a potassium ion channel / Anat Rec 250:465~474
Nagelhus EA / 2004 / Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1 / Neuroscience 129:905~913
Djukic B / 2007 / Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced shortterm synaptic potentiation / J Neurosci 27:11354~11365
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