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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 611 - 617 (7page)
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초록· 키워드
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Background: Anti-Gal is a major antibody induced in non-human primates (NHPs) after xenotransplantation. To understand the mechanism of graft rejection, we investigated the association between anti-Gal responses and graft failure in NHP recipients of porcine islet transplantation (PITx).
Methods: Intraportal PITx was performed in 35 diabetic NHPs, and graft function was monitored. Early graft failure (EGF) was defined as loss of graft function within a month after PITx. Seven, 19, nine NHPs received immunosuppression (IS) without CD40 pathway blockade (Group I), with anti-CD154 (Group II), and with anti-CD40 (Group III), respectively. The anti-Gal levels on day 0 and day 7 of PITx were measured by ELISA.
Results: The frequency of EGF was significantly lower in Group II (26.3%) than in Group I (100%, P=0.0012) and Group III (77.8%, P=0.0166). While levels of anti-Gal IgG in Group I and anti-Gal IgM in Group III increased on day 7 compared with day 0 (P=0.0156 and 0.0273), there was no increase in either on day 7 in Group II. The ratio of anti-Gal IgM or IgG level on day 7 to that on day 0 (Ratio7/0) was significantly higher in recipients with EGF than without EGF (P=0.0009 and 0.0027). ROC curve analysis of anti-Gal IgM Ratio7/0 revealed an area under the curve of 0.789 (P=0.0003).
Conclusions: IS with anti-CD154 suppressed anti-Gal responses and prevented EGF in PITx. Anti-Gal IgM Ratio7/0, being associated with EGF, is a predictive marker for EGF.
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등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Jin SM / 2011 / Islet isolation from adult designated pathogen-free pigs: use of the newer bovine nervous tissue-free enzymes and a revised donor selection strategy would improve the islet graft function / Xenotransplantation 18:369~379
Armitage RJ / 1992 / Molecular and biological characterization of a murine ligand for CD40 / Nature 357:80~82
van Essen D / 1995 / CD40 ligand-transduced co-stimulation of T cells in the development of helper function / Nature 378:620~623
Noelle RJ / 1992 / A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells / Proc Natl Acad Sci U S A 89:6550~6554
Mackey MF / 1998 / The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells / J Leukoc Biol 63:418~428
Armitage RJ / 1992 / Molecular and biological characterization of a murine ligand for CD40 / Nature 357:80~82
van Essen D / 1995 / CD40 ligand-transduced co-stimulation of T cells in the development of helper function / Nature 378:620~623
Noelle RJ / 1992 / A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells / Proc Natl Acad Sci U S A 89:6550~6554
Mackey MF / 1998 / The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells / J Leukoc Biol 63:418~428
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