지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 921 - 930 (10page)
이용수
초록· 키워드
오류제보하기
Purpose The purpose of this study was to evaluate whether an exogenous epidermal growth factor(EGF) could induce anti-tumor and radiosensitizing effects in vivo.
Materials and MethodsBALB/c-nu mice that were inoculated with A431 (human squamous cell carcinoma) cellsin the right hind legs were divided into five groups: I (no treatment), II (EGF for 6 days), III(EGF for 20 days), IV (radiotherapy [RT]), and V (RT plus concomitant EGF). EGF was administeredintraperitoneally (5 mg/kg) once a day and the RT dose was 30 Gy in six fractions.
Hematoxylin and eosin (H&E) stained sections of tumor, liver, lung, and kidney tissues wereinvestigated. Additionally, tumors were subjected to immunohistochemistry staining withcaspase-3.
ResultsEGF for 6 days decreased tumor volume, but it approached the level of the control group atthe end of follow-up (p=0.550). The duration of tumor shrinkage was prolonged in group Vwhile the slope of tumor re-growth phase was steeper in group IV (p=0.034). EGF for 20days decreased tumor volume until the end of the observation period (p < 0.001). Immunohistochemistryrevealed that mice in group V showed stronger intensity than those in groupIV. There were no abnormal histological findings upon H&E staining of the normal organs.
ConclusionEGF-induced anti-tumor effect was ascertained in the xenograft mouse models with A431cells. Concomitant use of EGF has the potential role as a radiosensitizer in the design offractionated irradiation.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bonner JA / 1994 / The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivitie
Bonner JA / 2010 / Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer : 5-year survival data from a phase 3 randomised trial, and relation between
Boonstra J / 1995 / The epidermal growth factor / Cell Biol Int 19 : 413 ~ 430
Cao L / 2000 / Epidermal growth factor induces cell cycle arrest and apoptosis of squamous carcinoma cells through reduction of cell adhesion / J Cell Biochem 77 : 569 ~ 583
Chiu B / 2007 / Novel action of epidermal growth factor on caspase 3 and its potential as a chemotherapeutic adjunct for neuroblastoma / J Pediatr Surg 42 : 1389 ~ 1395
Bonner JA / 2010 / Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer : 5-year survival data from a phase 3 randomised trial, and relation between
Boonstra J / 1995 / The epidermal growth factor / Cell Biol Int 19 : 413 ~ 430
Cao L / 2000 / Epidermal growth factor induces cell cycle arrest and apoptosis of squamous carcinoma cells through reduction of cell adhesion / J Cell Biochem 77 : 569 ~ 583
Chiu B / 2007 / Novel action of epidermal growth factor on caspase 3 and its potential as a chemotherapeutic adjunct for neuroblastoma / J Pediatr Surg 42 : 1389 ~ 1395
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
피부투과 기능성 펩타이드를 이용한 경피투과성 상피세포성장인자의 개발
대한화장품학회지
2019 .01
-
Wound Healing Effects of Rose Placenta in a Mouse Model of Full-Thickness Wounds
Archives of plastic surgery : APS
2015 .01
-
The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles
Annals of Dermatology
2017 .01
-
Retrospective analysis of tumor xenograft models for human cancer therapeutics
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Mouse tumor model and overview of surgical tumor model
한국실험동물학회 학술발표대회 논문집
2020 .02
-
A computerized method for measuring xenograft tumor volume enhances the accuracy and consistency of tumor size assessment in xenograft cancer models
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Clinical Implication of EGF A61G Polymorphism in the Risk of Non Small Cell Lung Adenocarcinoma Patients: A Case Control Study
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Preclinical Study of Novel Curcumin Analogue SSC-5 Using Orthotopic Tumor Xenograft Model for Esophageal Squamous Cell Carcinoma
Cancer Research and Treatment
2018 .01
-
Association Study of Polymorphisms of Epidermal Growth Factor and Epidermal Growth Factor Receptor With Benign Prostatic Hyperplasia in a Korean Population
International Neurourology Journal
2016 .12
-
Treatment of Partial-Thickness Burn Wounds with Combined Advanced Therapies: Cultured Allogenic Keratinocyte and Epidermal Growth Factor
Journal of Wound Management and Research
2023 .02
-
HT-29 암세포 이종이식으로 유발된 종양에 대한18β-Glycyrrhetinic Acid의 치료효과
약학회지
2015 .01
-
Gold nanoparticles enhance anti-tumor effect of radiotherapy to hypoxic tumor
Radiation oncology journal : ROJ
2016 .01
-
Established tumor model in nude mice using canine tumor cells, ChMP
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Radiation-induced immune responses: mechanisms and therapeutic perspectives
Blood Research
2016 .01
-
Effect of Epidermal Growth Factor with Collagen Matrix on Increasing Gingival Thickness: A Pilot Preclinical Investigation
Journal of Korean Dental Science
2023 .12
-
Multifocality and Bilaterality of Papillary Thyroid Microcarcinoma
Clinical and Experimental Otorhinolaryngology
2015 .01
-
Apatinib Combined with Local Irradiation Leads to Systemic Tumor Control via Reversal of Immunosuppressive Tumor Microenvironment in Lung Cancer
Cancer Research and Treatment
2020 .01
-
Altered Biological Potential and Radioresponse of Murine Tumors in Different Microenvironments
Cancer Research and Treatment
2016 .01
-
Association of tumor differentiation grade and survival of women with squamous cell carcinoma of the uterine cervix
Journal of Gynecologic Oncology
2018 .01
-
Pectolinarigenin suppresses the tumor growth in gastric cancer
한국실험동물학회 학술발표대회 논문집
2021 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0