지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 414 - 419 (6page)
이용수
초록· 키워드
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Background : T-SPOT.TB is a sensitive test that detects interferon-gamma producing T-cells in tuberculosis patients following stimulation with tuberculosis-specific antigens. Our study was aimed to investigate the possible causes of false negative results of the test by analyzing the patients with positive acid-fast bacilli (AFB) culture and negative T-SPOT.TB results.
Methods : We investigated 138 patients with positive AFB culture results reported between January 2009 and April 2010. Medical records of these patients were reviewed for the results of T-SPOT.TB test, AFB culture, PCR for Mycobacterium tuberculosis (TB-PCR), chest X-ray, drug treatment, etc.
Diagnosis of tuberculosis was confirmed by positive TB-PCR or identification of Mycobacterium tuberculosis (MTB). Sensitivity of T-SPOT.TB test was calculated and the possible causes of AFB culture positive and T-SPOT.TB negative results were analyzed.
Results : T-SPOT.TB test was performed in 63 of the 138 patients with AFB culture positive results. Fifty-six (88.9%) were positive and 7 patients (11.1%) were negative on T-SPOT.TB test. Of these 7 negative cases, 4 were confirmed as nontuberculous mycobacteria (NTM), 2 were suspected as NTM and diagnosis could not be confirmed in 1. Six of these 7 patients were over 70 yr old and 6 patients had lymphocytopenia. T-SPOT.TB negative results were not observed in any of the 44 patients confirmed to have active tuberculosis (sensitivity 100%).
Conclusions : Our results suggest that T-SPOT.TB test is very sensitive for diagnosing active tuberculosis. NTM may be the main cause of AFB culture positive and T-SPOT.TB negative results, but MTB infection in immunocompromised patients also has to be considered. (Korean J Lab Med 2010;30:414-9)
목차
등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
Kang YA / 2007 / Usefulness of whole-blood interferon-g assay and interferon-g enzymelinked immunospot assay in the diagnosis of active pulmonary tuberculosis / Chest 132 : 9
Kobashi Y / 2009 / False negative results of QuantiFERON TB-2G test in patients with active tuberculosis / Jpn J Infect Dis 62 : 300 ~ 302
Lee JY / 2006 / Comparison of two commercial interferon-gamma assays for diagnosing Mycobacterium tuberculosis infection / Eur Respir J 28 : 24 ~ 30
Liao CH / 2009 / Falsenegative results by enzyme-linked immunospot assay for interferon-gamma among patients with culture-confirmed tuberculosis / J Infect 59 : 421 ~ 423
Provinciali M / 2009 / Reference values for CD4+ and CD8+ T lymphocytes with naive or memory phenotype and their association with mortality in the elderly / Gerontology 55 :
Kobashi Y / 2009 / False negative results of QuantiFERON TB-2G test in patients with active tuberculosis / Jpn J Infect Dis 62 : 300 ~ 302
Lee JY / 2006 / Comparison of two commercial interferon-gamma assays for diagnosing Mycobacterium tuberculosis infection / Eur Respir J 28 : 24 ~ 30
Liao CH / 2009 / Falsenegative results by enzyme-linked immunospot assay for interferon-gamma among patients with culture-confirmed tuberculosis / J Infect 59 : 421 ~ 423
Provinciali M / 2009 / Reference values for CD4+ and CD8+ T lymphocytes with naive or memory phenotype and their association with mortality in the elderly / Gerontology 55 :
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