지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 427 - 433 (7page)
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초록· 키워드
오류제보하기
Background: Cotinine has been widely used as an objective marker to identify current smokers. We conducted this study to address the absence of Korean studies investigating the efficacy of immunoassays and liquid chromatography–tandem mass spectrometry (LC-MS/MS) for the detection of serum cotinine and to determine the optimal serum cotinine cut-off level for differentiating current smokers from nonsmokers.
Methods: Serum specimens were obtained from 120 subjects. They were randomly chosen to represent a broad distribution of urine cotinine levels based on a retrospective review of questionnaires and results of urine cotinine levels. We determined serum cotinine levels using the IMMULITE 2000 XPi Immunoassay System (Siemens Healthcare Diagnostics Inc., USA) and LC-MS/MS (API-4000, Applied Biosystems, USA). Correlation was analyzed between IMMULITE serum cotinine, urine cotinine, and LC-MS/MS serum cotinine levels. ROC curve was analyzed to identify the optimal IMMULITE serum cotinine cut-off level for differentiating current smokers from nonsmokers.
Results: IMMULITE serum cotinine levels correlated with both urine cotinine and LC-MS/MS serum cotinine levels, with correlation coefficients of 0.958 and 0.986, respectively. The optimal serum cotinine cut-off level for distinguishing current smokers from nonsmokers was 13.2 ng/mL (95.7% sensitivity, 94.1% specificity) using IMMULITE.
Conclusions: This is the first study to investigate the use of LC-MS/MS for the measurement of serum cotinine and to determine the optimal serum cotinine cut-off level for the IMMULITE immunoassay. Our results could provide guidelines for differentiating current smokers from nonsmokers in the Korean population.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Fielding JE / 1988 / Health effects of involuntary smoking / N Engl J Med 319:1452~1460
Stead LF / 2008 / Physician advice for smoking cessation / Cochrane Database Syst Rev :CD000165
Jemal A / 2008 / Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control / J Natl Cancer Inst 100:1672~1694
Jarvis MJ / 1987 / Comparison of tests used to distinguish smokers from nonsmokers / Am J Public Health 77:1435~1438
Binnie V / 2004 / The validation of self-reported smoking status by analysing cotinine levels in stimulated and unstimulated saliva, serum and urine / Oral Dis 10:287~293
Stead LF / 2008 / Physician advice for smoking cessation / Cochrane Database Syst Rev :CD000165
Jemal A / 2008 / Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control / J Natl Cancer Inst 100:1672~1694
Jarvis MJ / 1987 / Comparison of tests used to distinguish smokers from nonsmokers / Am J Public Health 77:1435~1438
Binnie V / 2004 / The validation of self-reported smoking status by analysing cotinine levels in stimulated and unstimulated saliva, serum and urine / Oral Dis 10:287~293
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