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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 595 - 598 (4page)
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초록· 키워드
오류제보하기
Amyloid β (Aβ) peptides are important components of plaques in patients with Alzheimer’s disease (AD). Recent studies suggest that a low plasma ratio of Aβ42 to Aβ40 may precede the development of the sporadic form of AD. The aim of this study was to establish reference intervals for plasma Aβ in Korean adults. A total of 370 apparently healthy individuals (181 males and 189 females aged 40-69 yr) without cognitive impairment were enrolled. Plasma concentrations of Aβ40 and Aβ42 were measured by using a human amyloid β assay kit (Immuno-Biological Laboratories, Japan). Reference intervals were established according to the “CLSI guidelines for defining, establishing, and verifying reference intervals in the clinical laboratory”. There was no need to partition the data with respect to gender or age group. The 95th percentile reference intervals for Aβ40 and Aβ42 were 127-331 pg/mL and 2.31-19.84 pg/mL, respectively. The reference interval for the Aβ42/Aβ40 ratio was 0.011-0.092. Plasma Aβ concentrations obtained in this study could be used as reference intervals for clinical purposes.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Knopman DS / 2003 / Essentials of the proper diagnoses of mild cognitive impairment, dementia, and major subtypes of dementia / Mayo Clin Proc 78:1290~1308
Knopman DS / 2001 / Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology / Neurology 56:1143~1153
Varon D / 2011 / Minimal atrophy of the entorhinal cortex and hippocampus: progression of cognitive impairment / Dement Geriatr Cogn Disord 31:276~283
Gaugler JE / 2013 / Sensitivity and specificity of diagnostic accuracy in Alzheimer’s disease: a synthesis of existing evidence / Am J Alzheimers Dis Other Demen 28:337~347
Vassar R / 2004 / BACE1: the beta-secretase enzyme in Alzheimer’s disease / J Mol Neurosci 23:105~114
Knopman DS / 2001 / Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology / Neurology 56:1143~1153
Varon D / 2011 / Minimal atrophy of the entorhinal cortex and hippocampus: progression of cognitive impairment / Dement Geriatr Cogn Disord 31:276~283
Gaugler JE / 2013 / Sensitivity and specificity of diagnostic accuracy in Alzheimer’s disease: a synthesis of existing evidence / Am J Alzheimers Dis Other Demen 28:337~347
Vassar R / 2004 / BACE1: the beta-secretase enzyme in Alzheimer’s disease / J Mol Neurosci 23:105~114
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