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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 28 - 33 (6page)
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초록· 키워드
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Background: Albuminuria is generally known as a sensitive marker of renal and cardiovascular dysfunction. It can be used to help predict the occurrence of nephropathy and cardiovascular disorders in diabetes. Individuals with prediabetes have a tendency to develop macrovascular and microvascular pathology, resulting in an increased risk of retinopathy, cardiovascular diseases, and chronic renal diseases. We evaluated the clinical value of a strip test for measuring the urinary albumin-to-creatinine ratio (ACR) in prediabetes and diabetes.
Methods: Spot urine samples were obtained from 226 prediabetic and 275 diabetic subjects during regular health checkups. Urinary ACR was measured by using strip and laboratory quantitative tests.
Results: The positive rates of albuminuria measured by using the ACR strip test were 15.5% (microalbuminuria, 14.6%; macroalbuminuria, 0.9%) and 30.5% (microalbuminuria, 25.1%; macroalbuminuria, 5.5%) in prediabetes and diabetes, respectively. In the prediabetic population, the sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of the ACR strip method were 92.0%, 94.0%, 65.7%, 99.0%, and 93.8%, respectively; the corresponding values in the diabetic population were 80.0%, 91.6%, 81.0%, 91.1%, and 88.0%, respectively. The median [interquartile range] ACR values in the strip tests for measurement ranges of <30, 30-300, and >300 mg/g were 9.4 [6.3-15.4], 46.9 [26.5-87.7], and 368.8 [296.2-575.2] mg/g, respectively, using the laboratory method.
Conclusions: The ACR strip test showed high sensitivity, specificity, and negative predictive value, suggesting that the test can be used to screen for albuminuria in cases of prediabetes and diabetes.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
American Diabetes Association / 2014 / Diagnosis and classification of diabetes mellitus / Diabetes Care 37 (S1) : S81 ~ S90
Dell’Omo G / 2002 / Association between high-normal albuminuria and risk factors for cardiovascular and renal disease in essential hypertensive men / Am J Kidney Dis 40 : 1
Diabetes Prevention Program Research Group / 2007 / The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the Diabetes Prevention Program /
Fioretto P / 2008 / The kidney in diabetes: dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007 / Diabetologia 51 : 1347 ~ 1355
Ford ES / 2010 / Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence / J Am Coll Cardiol 55 : 1310 ~ 1317
Dell’Omo G / 2002 / Association between high-normal albuminuria and risk factors for cardiovascular and renal disease in essential hypertensive men / Am J Kidney Dis 40 : 1
Diabetes Prevention Program Research Group / 2007 / The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the Diabetes Prevention Program /
Fioretto P / 2008 / The kidney in diabetes: dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007 / Diabetologia 51 : 1347 ~ 1355
Ford ES / 2010 / Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence / J Am Coll Cardiol 55 : 1310 ~ 1317
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