지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 351 - 358 (8page)
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초록· 키워드
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Objective: To evaluate the blood level of IGF-1 (insulin- like growth factor-1) and IGFBP-3 (insulin-like growth factor binding protein-3) in patients with post-acute stage brain diseases, and to investigate the relationship between IGF-1/ IGFBP-3 blood level and functional status in patients with post-acute stage brain diseases.
Method: Initial IGF-1/IGFBP-3 blood levels of 32 patients with post-acute stage brain disease were obtained and various functional indices, including modified Barthel index (MBI), functional ambulatory category (FAC), and Jebsen hand function test (JHFT), were assessed initially and at discharge.
Results: The IGF-1 blood level was normal in 23 patientsand decreased in 9. The IGFBP-3 blood level was normal in 20 patients and increased in 13. The initial IGF-1/IGFBP- 3 levels were associated with the change of MBI score during admission (p＜0.05, r2=0.214/p＜0.05, r2=0.213). There was a correlation between IGF-1/IGFBP-3 levels and JHFT score only on the unaffected side at discharge (p＜0.05, r2=0.278). There was no relation between IGF-1/IGFBP-3 levels and the change of JHFT score on either side during admission.
Conclusion: Initial IGF-1/IGFBP-3 blood level check can be a useful method to anticipate functional improvement of patients with post-acute stage brain disease.
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참고문헌 (26)
참고문헌 신청
/ / Comparison of protein synthesis in brain and peripheral tissue during aging. Relationship to insulin-like growth factor-1 and type 1 IGF receptors. Ann N Y Acad Sci 1993
/ / High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum. J Biol Chem 1989 : 1184
/ / Insulin-like growth factor-1 production is inhibited in human sepsis. Arch Surg 1988 : 1409 ~ 1414
/ / Plasma somatomedin acitivity after injury in man and its relationship to other hormonal and metabolic changes. Clin Endocrinol 1984 : 179 ~ 187
/ 1987 / Clinical utility of insulin-like growth factor assays 14 : 154 ~ 161
/ / High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum. J Biol Chem 1989 : 1184
/ / Insulin-like growth factor-1 production is inhibited in human sepsis. Arch Surg 1988 : 1409 ~ 1414
/ / Plasma somatomedin acitivity after injury in man and its relationship to other hormonal and metabolic changes. Clin Endocrinol 1984 : 179 ~ 187
/ 1987 / Clinical utility of insulin-like growth factor assays 14 : 154 ~ 161
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