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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 407 - 413 (7page)
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Purpose: The serum concentrations of insulin-like growth factors-I (IGF-I), insulin-like growth factor binding
protein-3 (IGFBP-3) and growth hormone (GH) are related to body composition, function and metabolism, and are
influenced by the aging process. This study was to investigate the influence of gender on serum concentrations of
IGF-I, IGFBP-3 and GH in middle and old age subjects. Materials and Methods: Sixty healthy volunteers (male
35, female 25, 36-70 years) were divided into ≤ 50 and > 50 years groups, based on gender. Women > 50 years were
post-menopause. IGF-I, IGFBP-3, and GH were determined by immunoradiometric assay. Results: IGF-I was
shown to be negatively correlated with age (women r = -0.62, p < 0.001; men r = -0.38, p < 0.05), whereas there was
no correlation between IGF-I and GH values. Women > 50 years showed a significant reduction in IGF-I values
than women ≤ 50 years (p < 0.01). Women > 50 years showed smaller IGF-I/IGFBP-3 molar ratios (0.177998 ±
0.039404) than men of same age group (0.228326 ± 0.050979, p < 0.01) and women ≤ 50 years (0.247667 ±
0.069411, p < 0.01). Age was shown to positively correlate with GH/IGF-I (r = 0.49, p < 0.05) and GH/IGFBP-3
ratios (r = 0.40, p < 0.05) in women. Conclusions: The influence of aging on serum concentrations of IGF-I is more
remarkable in women than in men. Menopause causes reduction of IGF-I/IGFBP-3 molar ratio. Women have the
trend of progressive hypoactivity of GH to stimulate IGF-I and IGFBP-3 secretions with age.
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참고문헌 (23)
참고문헌 신청
Aberg ND / 2006 / Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain / Scientif
Baglietto L / 2007 / Circulating insulin-like growth factor-I and binding protein-3 and the risk of breast cancer / Cancer Epidemiol Biomarkers Prev 16 : 763 ~ 768
Chan JM / 1998 / Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study / Science 279 : 563 ~ 566
Cohen P / 1998 / Serum insulin-like growth factor-I levels and prostate cancer risk--interpreting the evidence / J Natl Cancer Inst 90 : 876 ~ 879
Elsammak MY / 2006 / Possible contribution of serum activin A and IGF-1 in the development of hepatocellular carcinoma in Egyptian patients suffering from combined hepatitis
Baglietto L / 2007 / Circulating insulin-like growth factor-I and binding protein-3 and the risk of breast cancer / Cancer Epidemiol Biomarkers Prev 16 : 763 ~ 768
Chan JM / 1998 / Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study / Science 279 : 563 ~ 566
Cohen P / 1998 / Serum insulin-like growth factor-I levels and prostate cancer risk--interpreting the evidence / J Natl Cancer Inst 90 : 876 ~ 879
Elsammak MY / 2006 / Possible contribution of serum activin A and IGF-1 in the development of hepatocellular carcinoma in Egyptian patients suffering from combined hepatitis
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