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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 398 - 407 (10page)
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Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is considered a serious global threat. However, little is known regarding the multidrug resistance (MDR) mechanisms of CRKP. This study investigated the phenotypes and MDR mechanisms of CRKP and identified their clonal characteristics.
Methods: PCR and sequencing were utilized to identify antibiotic resistance determinants. Integron gene cassette arrays were determined by restriction fragment length polymorphism (RFLP) analysis. Multi-locus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE) were used for epidemiological analysis. Plasmids were typed by using a PCR-based replicon typing and analyzed by conjugation and transformation assays.
Results: Seventy-eight strains were identified as resistant to at least one carbapenem; these CRKP strains had a high prevalence rate (38.5%, 30/78) of carbapenemase producers. Additionally, most isolates harbored MDR genes, including Extended spectrum β-lactamases (ESBLs), AmpC, and quinolone and aminoglycoside resistance genes. Loss of porin genes was observed, and Class 1 integron was detected in 66.7% of the investigated isolates. PFGE and MLST results excluded the occurrence of clonal dissemination among these isolates.
Conclusions: A high prevalence of NDM-1 genes encoding carbapenem resistance determinants was demonstrated among the K. pneumoniae isolates. Importantly, this is the first report of blaNDM-1 carriage in a K. pneumoniae ST1383 clone in China and of a MDR CRKP isolate co-harboring blaNDM-1, blaKPC-2, blaCTX-M, blaSHV, acc(6’)-Ib, rmtB, qnrB, and acc(6’)-Ib-cr.
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참고문헌 (39)
참고문헌 신청
Endimiani A / 2009 / Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA / J Antimicrob. Chemother 63:427~437
Kumarasamy KK / 2010 / Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study / Lancet Infect Dis 10:597~602
Ranjan A / 2016 / Molecular epidemiology and genome dynamics of New Delhi Metallo-β-Lactamase-producing extraintestinal pathogenic Escherichia coli strains from India / Antimicrob Agents Chemother 60:6795~6805
Zowawi HM / 2014 / Molecular characterization of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the countries of the Gulf cooperation council: dominance of OXA-48 and NDM producers / Antimicrob Agents Chemother 58:3085~3090
Gharout-Sait A / 2014 / Enterobacteriaceae isolates carrying the New Delhi mettallo-β-lactamase gene in Yemen / J Med Microbiol 63:1316~1323
Kumarasamy KK / 2010 / Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study / Lancet Infect Dis 10:597~602
Ranjan A / 2016 / Molecular epidemiology and genome dynamics of New Delhi Metallo-β-Lactamase-producing extraintestinal pathogenic Escherichia coli strains from India / Antimicrob Agents Chemother 60:6795~6805
Zowawi HM / 2014 / Molecular characterization of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the countries of the Gulf cooperation council: dominance of OXA-48 and NDM producers / Antimicrob Agents Chemother 58:3085~3090
Gharout-Sait A / 2014 / Enterobacteriaceae isolates carrying the New Delhi mettallo-β-lactamase gene in Yemen / J Med Microbiol 63:1316~1323
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