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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 362 - 366 (5page)
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초록· 키워드
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Background: Antibodies specific to human neutrophil antigen (HNA), especially HNA-2, are implicated in various conditions, including neonatal alloimmune neutropenia, febrile non-hemolytic transfusion reactions, and transfusion-related acute lung injury. The distribution of the HNA-2 phenotype frequencies in the Thai population remains unknown. This study aimed to investigate HNA-2 phenotype frequencies in Thai blood donors and to compare the relationships of sex and age with HNA-2 expression. Methods: EDTA blood samples were collected from 220 unrelated healthy Thai blood donors, including 150 males and 70 females, with ages ranging from 20 to 57 years. Polymorphonuclear cells were isolated and stained with monoclonal antibodies clone MEM- 166 and clone 2D1, which are specific to human CD177 (HNA-2) and CD45, respectively. HNA-2 expression according to sex and age was analyzed by flow cytometry. Results: Among the 220 donors, HNA-2-positive and HNA-2-null-phenotype frequencies were 0.995 and 0.005, respectively. Mean antigen expression was significantly higher in women (71.01±15.46%) than in men (64.59±18.85%; P <0.05). No significant differences in HNA-2 expression were found between different age groups. HNA-2 phenotype frequencies were similar to those in Asian, African, American, and Brazilian populations, but were significantly different from those in eastern Japanese, Korean, and French populations (P <0.001). Conclusions: This is the first report of HNA-2 phenotype frequencies in a Thai population, and the data will be helpful in predicting the risk of HNA-2 alloimmunization and in recruiting granulocyte panel donors.
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참고문헌 (28)
참고문헌 신청
Lalezari P / 1971 / NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia / J Clin Invest 50:1108~1115
Moritz E / 2009 / Human neutrophil alloantigens systems / An Acad Bras Cienc 81:559~569
Stroncek DF / 1990 / Biochemical characterization of the neutrophil-specific antigen NB1 / Blood 75:744~755
Wolff J / 2003 / Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms / Blood 102:731~733
Flesch BK / 2015 / Human neutrophil antigens: a nomenclature update based on new alleles and new antigens / VOXS 10(S1):243~249
Moritz E / 2009 / Human neutrophil alloantigens systems / An Acad Bras Cienc 81:559~569
Stroncek DF / 1990 / Biochemical characterization of the neutrophil-specific antigen NB1 / Blood 75:744~755
Wolff J / 2003 / Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms / Blood 102:731~733
Flesch BK / 2015 / Human neutrophil antigens: a nomenclature update based on new alleles and new antigens / VOXS 10(S1):243~249
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