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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 189 - 195 (7page)
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초록· 키워드
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Clostridium difficile is a major causative agent of antibiotic-associated diarrhea and has become the most common pathogen of healthcare-associated infection worldwide. The pathogenesis of C. difficile infection (CDI) is mediated by many factors such as colonization involving attachment to host intestinal epithelial cells, sporulation, germination, and toxin production. Bacterial cell surface components are crucial for the interaction between the bacterium and host cells. C. difficile has two distinct surface layer proteins (SLPs): a conserved high-molecular-weight SLP and a highly variable low-molecular-weight SLP. Recent studies have shown that C. difficile SLPs play roles not only in growth and survival, but also in adhesion to host epithelial cells and induction of cytokine production. Sequence typing of the variable region of the slpA gene, which encodes SLPs, is one of the methods currently used for typing C. difficile. SLPs have received much attention in recent years as vaccine candidates and new therapeutic agents in the treatment of C. difficile-associated diseases. Gaining mechanistic insights into the molecular functions of C. difficile SLPs will help advance our understanding of CDI pathogenesis and the development of vaccines and new therapeutic approaches. In this review, we summarize the characteristics and immunological roles of SLPs in C. difficile.
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참고문헌 (71)
참고문헌 신청
Collins MD / 1994 / The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species combinations / Int J Syst Bacteriol 44:812~826
Yutin N / 2013 / A genomic update on clostridial phylogeny: Gram-negative spore formers and other misplaced clostridia / Environ Microbiol 15:2631~2641
Lawson PA / 2016 / Reclassification of Clostridium difficile as Clostridioides difficile (Hall and O'Toole 1935) Prevot 1938 / Anaerobe 40:95~99
Oren A / 2015 / List of new names and new combinations previously effectively, but not validly, published / Int J Sys Evol Microbiol 65:3763~3767
Lessa FC / 2015 / Burden of Clostridium difficile infection in the United States / N Engl J Med 372:825~834
Yutin N / 2013 / A genomic update on clostridial phylogeny: Gram-negative spore formers and other misplaced clostridia / Environ Microbiol 15:2631~2641
Lawson PA / 2016 / Reclassification of Clostridium difficile as Clostridioides difficile (Hall and O'Toole 1935) Prevot 1938 / Anaerobe 40:95~99
Oren A / 2015 / List of new names and new combinations previously effectively, but not validly, published / Int J Sys Evol Microbiol 65:3763~3767
Lessa FC / 2015 / Burden of Clostridium difficile infection in the United States / N Engl J Med 372:825~834
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