지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제14권 제3호
- 발행연도
- 2016.1
- 수록면
- 256 - 260 (5page)
이용수
초록· 키워드
오류제보하기
Objective: The prevalence of schizophrenia is 1%, and it is a debilitating disorder that often results in a shortened lifespan.
Peripheral blood samples are good candidates to investigate because they can be easily drawn, and they are widely studied in psychiatric disorders. MicroRNAs are small non-coding RNA transcripts. They regulate the expression of genes by binding to the 3’-untranslated region (UTR) of mRNAs and pointing them to degrade. In this study, we aimed to investigate the expression of miR-9-5p, miR-29a-3p, miR-106-5p, miR-106b-5p, miR-107, miR-125a-3p, and miR-125b-3p in schizophrenia patients and healthy controls.
Methods: We collected blood samples from 16 patients with schizophrenia and 16 healthy controls. MicroRNAs were measured with reverse transcriptase polymerase chain reaction.
Results: Schizophrenia patients showed statistically significant upregulation of five microRNAs: miR9-5p (p=0.002), miR29a-3p (p＜0.001), miR106b-5p (p=0.002), miR125a-3p (p＜0.001), and miR125b-3p (p=0.018).
Conclusion: Our results increased the value of the miR106 and miR29 families as potentially and consistently dysregulated in psychiatric disorders. Our results should be considered preliminary, and they need confirmation in future studies with larger sample sizes.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Anupa A. Vijayakumari / 2015 / Effect of Polymorphisms of Three Genes Mediating Monoamine Signalling on Brain Morphometry in Schizophrenia and Healthy Subjects / Clinical Psychopharmacology and Neuroscience 13(1):68~82
Carissa Nadia Kuswanto / 2012 / Diffusion Tensor Imaging Findings of White Matter Changes in First Episode Schizophrenia: A Systematic Review / Clinical Psychopharmacology and Neuroscience 10(1):13~24
Annya M. Smyth / 2013 / The Neuroimmunology of Schizophrenia / Clinical Psychopharmacology and Neuroscience 11(3):107~117
Biomarkers Definitions Working Group / 2001 / Biomarkers and surrogate endpoints: preferred definitions and conceptual framework / Clin Pharmacol Ther 69:89~95
Camkurt MA / 2015 / Comparison of plasma MicroRNA levels in drug naive, first episode depressed patients and healthy controls / J Psychiatr Res 69:67~71
Carissa Nadia Kuswanto / 2012 / Diffusion Tensor Imaging Findings of White Matter Changes in First Episode Schizophrenia: A Systematic Review / Clinical Psychopharmacology and Neuroscience 10(1):13~24
Annya M. Smyth / 2013 / The Neuroimmunology of Schizophrenia / Clinical Psychopharmacology and Neuroscience 11(3):107~117
Biomarkers Definitions Working Group / 2001 / Biomarkers and surrogate endpoints: preferred definitions and conceptual framework / Clin Pharmacol Ther 69:89~95
Camkurt MA / 2015 / Comparison of plasma MicroRNA levels in drug naive, first episode depressed patients and healthy controls / J Psychiatr Res 69:67~71
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