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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제16권 제1호
- 발행연도
- 2018.1
- 수록면
- 32 - 38 (7page)
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초록· 키워드
오류제보하기
Objective: Recent studies suggest a possible involvement of low paraoxonase 1 (PON1) enzyme activities in the association between schizophrenia, treatment with atypical antipsychotics and increased cardiovascular (CVD) risk. In the present study, we aimed at investigating the PON1 status in a group of schizophrenic patients treated with either olanzapine or other antipsychotic, as compared to a group of healthy control participants. Methods: We assessed the arylesterase (AREase) and paraoxonase (POase) activities of PON1, as well as three common polymorphisms of PON1 gene (Q192R, L55M, −108C＞T). Results: We found significantly lower (−13.3%) AREase activity in schizophrenic patients, along with significantly lower (−18.2%) POase activity in olanzapine-treated patients with QQ genotype. Furthermore, we found a significant difference between groups in L55M polymorphism distribution, whereas Q192R and −108C＞T polymorphisms distributions were similar. Conclusion: We identified the olanzapine-treated patients with QQ genotype as having the lowest PON1 (POase) activity, providing a possible way of identifying schizophrenic patients exposed to the greatest risk of CVD.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Bruijnzeel D / 2014 / Antipsychotic treatment of schizophrenia: an update / Asian J Psychiatr 11:3~7
Haro JM / 2006 / The SOHO (Schizophrenia Outpatient Health Outcome) study: implications for the treatment of schizophrenia / CNS Drugs 20:293~301
Yogaratnam J / 2013 / Metabolic complications of schizophrenia and antipsychotic medications--an updated review / East Asian Arch Psychiatry 23:21~28
Sarandol A / 2007 / Coronary artery disease risk factors in patients with schizophrenia: effects of short term antipsychotic treatment / J Psychopharmacol 21:857~863
Janicak PG / 2014 / Schizophrenia: recent advances in diagnosis and treatment / Springer :239~240
Haro JM / 2006 / The SOHO (Schizophrenia Outpatient Health Outcome) study: implications for the treatment of schizophrenia / CNS Drugs 20:293~301
Yogaratnam J / 2013 / Metabolic complications of schizophrenia and antipsychotic medications--an updated review / East Asian Arch Psychiatry 23:21~28
Sarandol A / 2007 / Coronary artery disease risk factors in patients with schizophrenia: effects of short term antipsychotic treatment / J Psychopharmacol 21:857~863
Janicak PG / 2014 / Schizophrenia: recent advances in diagnosis and treatment / Springer :239~240
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