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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 232 - 238 (7page)
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초록· 키워드
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ObjectiveaaTo study whether the effects of olanzapine on gastrointestinal motility is related to the serotonin antagonism and myosin light chain kinase.
MethodsaaMale Sprague-Dawley rats were randomly divided into four groups. Olanzapine gavage was performed for each treatment group during the course of 30 continuous days, while the same volume of saline was given to the rats in the control group. Defecation of the rats was observed on days 7 and 30 after olanzapine gavage. The effects of olanzapine on contraction of colonic smooth muscles were observed in ex vivo experiments. A Western blot was used to evaluate expression levels of the serotonin transporter (SERT) and MLCK in colon segments of the rats.
ResultsaaCompared to the control group, 5–160 μM of olanzapine could inhibit dose-dependently the contraction of colonic smooth muscle ex vivo experiments. The maximum smooth muscle contraction effects of 5-HT and acetylcholine significantly decreased after treatment with 40–160 μM of olanzapine. Constipation was found in the olanzapine-treated rats on day 7 and have sustained day 30 after gavage. Expression of MLCK in olanzapine-treated rats was significantly decreased, whereas the expression of SERT significantly increased on the day 7, then significantly decreased on the day 30 after olanzapine gavage.
ConclusionaaSERT and MLCK may involve in the inhibition of colonic contraction induced by olanzapine.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Prommer E / 2013 / Olanzapine : palliative medicine update / Am J Hosp Palliat Care 30:75~82
Kelly DL / 2006 / Plasma concentrations of high-dose olanzapine in a double-blind crossover study / Hum Psychopharmacol 21:393~398
Chew ML / 2006 / A model of anticholinergic activity of atypical antipsychotic medications / Schizophr Res 88:63~72
Rege S / 2008 / Life-threatening constipation associated with clozapine / Australas Psychiatry 16:216~219
Bymaster FP / 1999 / Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro / Schizophr Res 37:107~122
Kelly DL / 2006 / Plasma concentrations of high-dose olanzapine in a double-blind crossover study / Hum Psychopharmacol 21:393~398
Chew ML / 2006 / A model of anticholinergic activity of atypical antipsychotic medications / Schizophr Res 88:63~72
Rege S / 2008 / Life-threatening constipation associated with clozapine / Australas Psychiatry 16:216~219
Bymaster FP / 1999 / Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro / Schizophr Res 37:107~122
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