지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제14권 제1호
- 발행연도
- 2016.1
- 수록면
- 43 - 48 (6page)
이용수
초록· 키워드
오류제보하기
Objective: This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression.
Methods: This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck’s Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA.
Results: The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, but IGF-1 was significantly higher in those with than in those without depression.
Conclusion: IGF-1 was found to be associated with depression in alcohol-dependent patients, suggesting that IGF-1 in alcohol- dependent patients could be an important biomarker to indicate whether alcohol-dependence is accompanied by depression.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Kessler RC / 1996 / The epidemiology of co-occurring addictive and mental disorders: implications for prevention and service utilization / Am J Orthopsychiatry 66:17~31
Kessler RC / 1997 / Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey / Arch Gen Psychiatry 54:313~321
Regier DA / 1990 / Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study / JAMA 264:2511~2518
Cornelius JR / 1995 / Disproportionate suicidality in patients with comorbid major depression and alcoholism / Am J Psychiatry 152:358~364
Davis LL / 2005 / Substance use disorder comorbidity in major depressive disorder: an exploratory analysis of the Sequenced Treatment Alternatives to Relieve Depression cohort / Compr Psychiatry 46:81~89
Kessler RC / 1997 / Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey / Arch Gen Psychiatry 54:313~321
Regier DA / 1990 / Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study / JAMA 264:2511~2518
Cornelius JR / 1995 / Disproportionate suicidality in patients with comorbid major depression and alcoholism / Am J Psychiatry 152:358~364
Davis LL / 2005 / Substance use disorder comorbidity in major depressive disorder: an exploratory analysis of the Sequenced Treatment Alternatives to Relieve Depression cohort / Compr Psychiatry 46:81~89
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