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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제16권 제2호
- 발행연도
- 2018.1
- 수록면
- 144 - 152 (9page)
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Objective: Although several prior works showed the white matter (WM) integrity changes in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease, it is still unclear the diagnostic accuracy of the WM integrity measurements using diffusion tensor imaging (DTI) in discriminating aMCI from normal controls. The aim of this study is to explore diagnostic validity of whole brain automated probabilistic tractography in discriminating aMCI from normal controls. Methods: One hundred-two subjects (50 aMCI and 52 normal controls) were included and underwent DTI scans. Whole brain WM tracts were reconstructed with automated probabilistic tractography. Fractional anisotropy (FA) and mean diffusivity (MD) values of the memory related WM tracts were measured and compared between the aMCI and the normal control groups. In addition, the diagnostic validities of these WM tracts were evaluated. Results: Decreased FA and increased MD values of memory related WM tracts were observed in the aMCI group compared with the control group. Among FA and MD value of each tract, the FA value of left cingulum angular bundle showed the highest area under the curve (AUC) of 0.85 with a sensitivity of 88.2%, a specificity of 76.9% in differentiating MCI patients from control subjects. Furthermore, the combination FA values of WM integrity measures of memory related WM tracts showed AUC value of 0.98, a sensitivity of 96%, a specificity of 94.2%. Conclusion: Our results with good diagnostic validity of WM integrity measurements suggest DTI might be promising neuroimaging tool for early detection of aMCI and AD patients.
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참고문헌 (52)
참고문헌 신청
Brodaty H / 2011 / The world of dementia beyond 2020 / J Am Geriatr Soc 59:923~927
Cui Y / 2012 / Automated detection of amnestic mild cognitive impairment in community-dwelling elderly adults: a combined spatial atrophy and white matter alteration approach / Neuroimage 59:1209~1217
Hu Z / 2014 / Advances in longitudinal studies of amnestic mild cognitive impairment and Alzheimer's disease based on multi-modal MRI techniques / Neurosci Bull 30:198~206
Petersen RC / 2010 / Prevalence of mild cognitive impairment is higher in men. The mayo clinic study of aging / Neurology 75:889~897
Citron M / 2010 / Alzheimer's disease: strategies for disease modification / Nat Rev Drug Discov 9:387~398
Cui Y / 2012 / Automated detection of amnestic mild cognitive impairment in community-dwelling elderly adults: a combined spatial atrophy and white matter alteration approach / Neuroimage 59:1209~1217
Hu Z / 2014 / Advances in longitudinal studies of amnestic mild cognitive impairment and Alzheimer's disease based on multi-modal MRI techniques / Neurosci Bull 30:198~206
Petersen RC / 2010 / Prevalence of mild cognitive impairment is higher in men. The mayo clinic study of aging / Neurology 75:889~897
Citron M / 2010 / Alzheimer's disease: strategies for disease modification / Nat Rev Drug Discov 9:387~398
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