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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 251 - 256 (6page)
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초록· 키워드
오류제보하기
Objectives：Most studies of hippocampal metabolism(HM) in amnestic mild cognitive impairment(aMCI) gave inconsistent results. Our objective was to evaluate the effect of amyloid-beta(Aβ) status on hippocampal metabolism in aMCI.
Methods：Overall, 23 aMCI underwent three-dimensional magnetic resonance imaging(MRI), <SUP>18</SUP>F-fluorodeoxyglucose-positron emission tomography(<SUP>18</SUP>FDG-PET) and <SUP>18</SUP>F-Fluorbetaben amyloid positron emission tomography (amyloid-PET). According to Aβ status on amyloid PET, 23 aMCI were classified as either Aβ+aMCI(N=13) or Aβ-aMCI(N=10). The primary outcome was HM using <SUP>18</SUP>FDG-PET and we investigate the difference on HM between Aβ+aMCI and Aβ-aMCI using analysis of variance(ANOVA) model, after controlling hippocampal volume.
Results：We found that HM was more decreased in Aβ+aMCI than Aβ-aMCI. This result was not changed after controlling hippocampal volume.
Conclusion：Our findings suggest that Aβ+ is associated with decreased HM, regardless of hippocampal volume, in aMCI.
Methods：Overall, 23 aMCI underwent three-dimensional magnetic resonance imaging(MRI), <SUP>18</SUP>F-fluorodeoxyglucose-positron emission tomography(<SUP>18</SUP>FDG-PET) and <SUP>18</SUP>F-Fluorbetaben amyloid positron emission tomography (amyloid-PET). According to Aβ status on amyloid PET, 23 aMCI were classified as either Aβ+aMCI(N=13) or Aβ-aMCI(N=10). The primary outcome was HM using <SUP>18</SUP>FDG-PET and we investigate the difference on HM between Aβ+aMCI and Aβ-aMCI using analysis of variance(ANOVA) model, after controlling hippocampal volume.
Results：We found that HM was more decreased in Aβ+aMCI than Aβ-aMCI. This result was not changed after controlling hippocampal volume.
Conclusion：Our findings suggest that Aβ+ is associated with decreased HM, regardless of hippocampal volume, in aMCI.
목차
서론
대상 및 방법
결과
고찰
참고문헌
참고문헌 (26)
참고문헌 신청
Petersen RC / 2016 / Mild cognitive impairment / Continuum(Minneap Minn) 22:404~418
Li JQ / 2016 / Risk factors for predicting progression from mild cognitive impairment to Alzheimer’s disease : a systematic review and meta-analysis of cohort studies / J Neurol Neurosurg Psychiatry 87:476~484
Hyman BT / 1986 / Perforant pathway changes and the memory impairment of Alzheimer’s disease / Ann Neurol 20:472~481
Bartsch T / 2011 / CA1 neurons in the human hippocampus are critical for autobiographical memory, mental time travel, and autonoetic consciousness / Proc Natl Acad Sci U S A 108:17562~17567
Pagani M / 2010 / MCI patients declining and not-declining at mid-term follow-up : FDG-PET findings / Curr Alzheimer Res 7:287~294
Li JQ / 2016 / Risk factors for predicting progression from mild cognitive impairment to Alzheimer’s disease : a systematic review and meta-analysis of cohort studies / J Neurol Neurosurg Psychiatry 87:476~484
Hyman BT / 1986 / Perforant pathway changes and the memory impairment of Alzheimer’s disease / Ann Neurol 20:472~481
Bartsch T / 2011 / CA1 neurons in the human hippocampus are critical for autobiographical memory, mental time travel, and autonoetic consciousness / Proc Natl Acad Sci U S A 108:17562~17567
Pagani M / 2010 / MCI patients declining and not-declining at mid-term follow-up : FDG-PET findings / Curr Alzheimer Res 7:287~294
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