지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제2호
- 발행연도
- 2017.1
- 수록면
- 170 - 176 (7page)
이용수
초록· 키워드
오류제보하기
Objective: In bipolar disorder, serum brain-derived neurotrophic factor (BDNF) level decreases leading to dysfunctions of critical neurotrophic, cellular plasticity and neuroprotective processes. The present study was conducted to evaluate the change in serum BDNF level with oxcarbazepine monotherapy in bipolar mania.
Methods: The present study is a prospective, interventional, open label clinical study conducted on 25 patients of bipolar mania and 25 healthy controls. Detailed history, clinical evaluation including Young Mania Rating Scale (YMRS) scoring and serum BDNF were assessed at baseline for all 50 subjects. The bipolar patients were prescribed tablet oxcarbazepine and followed up after 4 weeks for clinical evaluation and re-estimation of serum BDNF and YMRS scoring.
Results: The serum BDNF level in bipolar manic patients were compared with healthy controls at baseline and results revealed that there is a significant reduction (p=0.002) in serum BDNF level in bipolar patients. At follow-up after 4 weeks, the mean change in serum BDNF in bipolar group who were on oxcarbazepine monotherapy was found statistically significant (p=0.02) in comparison to healthy controls. In bipolar group, the YMRS score and serum BDNF at baseline have an inverse relation(r=−0.59) whereas change of the YMRS score had a positive correlation (r=0.67) with the change of serum BDNF over 4 weeks.
Conclusion: In bipolar mania serum BDNF level is low and it is found to be increased with short term monotherapy with oxcarbazepine.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Cunha AB / 2006 / Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes / Neurosci Lett 398 : 215 ~ 219
Fernandes BS / 2011 / Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders : a systematic review and meta-regression analysis / J Psychi
Fernandes BS / 2015 / Peripheral brain-derived neurotrophic factor(BDNF)as a biomarker in bipolar disorder : a meta-analysis of 52 studies / BMC Med 13 : 289 ~
Frey BN / 2013 / Biomarkers in bipolar disorder : a positional paper from the International Society for Bipolar Disorders Biomarkers Task Force / Aust N Z J Psychiatry 47 : 3
Ghaemi SN / 2002 / Oxcarbazepine treatment of refractory bipolar disorder : a retrospective chart review / Bipolar Disord 4 : 70 ~ 74
Fernandes BS / 2011 / Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders : a systematic review and meta-regression analysis / J Psychi
Fernandes BS / 2015 / Peripheral brain-derived neurotrophic factor(BDNF)as a biomarker in bipolar disorder : a meta-analysis of 52 studies / BMC Med 13 : 289 ~
Frey BN / 2013 / Biomarkers in bipolar disorder : a positional paper from the International Society for Bipolar Disorders Biomarkers Task Force / Aust N Z J Psychiatry 47 : 3
Ghaemi SN / 2002 / Oxcarbazepine treatment of refractory bipolar disorder : a retrospective chart review / Bipolar Disord 4 : 70 ~ 74
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