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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제1호
- 발행연도
- 2017.1
- 수록면
- 59 - 63 (5page)
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초록· 키워드
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Objective: The present study aims to analyze the levels of resistin, tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-18, and C-reactive protein (CRP) in patients with Alzheimer’s disease (AD) and also investigate a potential relationship between resistin levels and TNF-α, IL-1β, IL-6, IL-18, and CRP levels in patients with AD.
Methods: The study included fifty patients with AD and 30 healthy controls with normal cognitive functions. The serum resistin, TNF-α, IL-1β, IL-6, IL-18, and CRP levels were assessed. We performed a Mini-Mental State Examination (MMSE) to evaluate the general cognitive performance.
Results: The mean serum resistin, IL-1β, IL-18, and TNF-α levels were significantly higher in patients with AD compared with the controls (p=0.026, p=0.002, p=0.003, and p=0.038, respectively). The IL-6 and CRP levels did not differ between the groups (p=0.874 and p=0.941). The resistin levels were positively correlated with the levels of CRP and IL-18 (r=0.526, p＜0.001; r=0.402, p=0.004, respectively). MMSE scores and inflammatory markers were not correlated (p＞0.05 for all).
Conclusion: Serum resistin levels were significantly increased and correlated with some inflammatory markers in AD patients, suggesting that resistin might play a role in the inflammatory process of AD.
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참고문헌 (24)
참고문헌 신청
Alam Q / 2016 / Inflammatory process in Alzheimer's and Parkinson's diseases : Central role of cytokines / Curr Pharm Des 22 : 541 ~ 548
Alzheimer’s Disease International / / World alzheimer report 2014: Dementia and risk reduction-an analysis of protective and modifiable factors
Axelsson J / 2006 / Elevated resistin levels in chronic kidney disease are associated with decreased glomerular filtration rate and inflammation, but not with insulin resist
Cacabelos R / 1994 / Brain interleukin-1 beta in Alzheimer's disease and vascular dementia / Methods Find Exp Clin Pharmacol 16 : 141 ~ 151
Chai NC / 2015 / Ictal adipokines are associated with pain severity and treatment response in episodic migraine / Neurology 84 : 1409 ~ 1418
Alzheimer’s Disease International / / World alzheimer report 2014: Dementia and risk reduction-an analysis of protective and modifiable factors
Axelsson J / 2006 / Elevated resistin levels in chronic kidney disease are associated with decreased glomerular filtration rate and inflammation, but not with insulin resist
Cacabelos R / 1994 / Brain interleukin-1 beta in Alzheimer's disease and vascular dementia / Methods Find Exp Clin Pharmacol 16 : 141 ~ 151
Chai NC / 2015 / Ictal adipokines are associated with pain severity and treatment response in episodic migraine / Neurology 84 : 1409 ~ 1418
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