지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 16 - 26 (11page)
이용수
초록· 키워드
오류제보하기
Atopic dermatitis (AD) is the most common pruritic inflammatory skin disease characterized by thickening of epidermis and dermis as well as by the infiltration of multiple pathogenic polarized T lymphocytes, including Th2, Th17, and Th22 cells. Significant progress has been made to develop targeted therapeutics for treating AD, e.g., Food and Drug Administrationapproved dupilumab, an antibody for dual targeting of IL-4 and IL-13 signaling pathways. Additionally, a growing body of published evidence and a promising result from the early stage of the clinical trial with ILV-094, an anti-IL-22 antibody, strongly support the notion that IL-22 is a potential therapeutic target for treating AD. Moreover, we also experimentally proved that IL-22 contributes to the pathophysiology of AD by employing a murine model of AD induced by epicutaneous sensitization. Here, we review recent preclinical and clinical findings that have advanced our understanding of the roles of IL-22 and Th22 cells in skin inflammation. We conclude that blockade of IL-22 signaling may be a promising therapeutic approach for the treatment of AD.
목차
ABSTRACT
INTRODUCTION
THE SKIN AS A MAJOR ROUTE OF ALLERGEN SENSITIZATION FOR ALLERGIC DISEASES
MOUSE MODEL OF AD TRIGGERED BY EPICUTANEOUSSENSITIZATION
POTENTIAL ROLE OF IL-22 AND TH22 CELLS IN AD
PLAUSIBLE MECHANISMS OF TH22 CELL POLARIZATIONIN THE SKIN
POTENTIAL THERAPEUTIC TARGETING OF IL-22/TH22SIGNALING PATHWAYS IN AD
ALTERNATIVE THERAPEUTIC APPROACHES FOR THETREATMENT OF AD
FUTURE PERSPECTIVES
REFERENCES
참고문헌 (82)
참고문헌 신청
2016 / Patient perspectives: atopic dermatitis (eczema) / Pediatr Dermatol 33:85~86
Bieber T / 2016 / Global Allergy Forum and 3rd Davos Declaration 2015: atopic dermatitis/eczema: challenges and opportunities toward precision medicine / Allergy 71:588~592
Flohr C / 2014 / New insights into the epidemiology of childhood atopic dermatitis / Allergy 69:3~16
Leung DY / 2014 / Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches / J Allergy Clin Immunol 134:769~779
Brunner PM / 2017 / The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies / J Allergy Clin Immunol 139:S65~S76
Bieber T / 2016 / Global Allergy Forum and 3rd Davos Declaration 2015: atopic dermatitis/eczema: challenges and opportunities toward precision medicine / Allergy 71:588~592
Flohr C / 2014 / New insights into the epidemiology of childhood atopic dermatitis / Allergy 69:3~16
Leung DY / 2014 / Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches / J Allergy Clin Immunol 134:769~779
Brunner PM / 2017 / The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies / J Allergy Clin Immunol 139:S65~S76
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Therapeutic New Era for Atopic Dermatitis: Part 1. Biologics
Annals of Dermatology
2021 .01
-
Polyphenol-rich Sargassum horneri alleviates atopic dermatitis-like skin lesions in NC/Nga mice by suppressing Th-2 mediated cytokine IL-13
한국실험동물학회 학술발표대회 논문집
2021 .07
-
아토피피부염 환아에서 interleukin-31 및 25-hydroxyvitamin D의 혈청 수치와 아토피피부염의 중증도와의 상관관계
Allergy Asthma & Respiratory Diseases
2015 .01
-
IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance
Immune Network
2024 .06
-
Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children
Korean journal of pediatrics
2015 .01
-
Noninvasive Detection of Specific Diagnostic Biomarkers for Atopic Dermatitis
대한의생명과학회지
2019 .03
-
Interactions Between IL-17 Variants and Streptococcus in the Gut Contribute to the Development of Atopic Dermatitis in Infancy
Allergy, Asthma & Immunology Research
2021 .01
-
Optimization of Cytokine Milieu to Reproduce Atopic Dermatitis-related Gene Expression in HaCaT Keratinocyte Cell Line
Immune Network
2018 .04
-
호마자 추출물이 NC/Nga 생쥐의 아토피 피부염에 미치는 영향
대한한방소아과학회지
2015 .01
-
아토피피부염 동물 병태 모델에서 아토탕의 개선효과
대한본초학회지(본초분과학회지)
2016 .01
-
Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
2020 .01
-
Natural History and Risk Factors of Atopic Dermatitis in Children
Allergy, Asthma & Immunology Research
2015 .01
-
한국 소아 아토피피부염의 연구 현황과 과제
Allergy Asthma & Respiratory Diseases
2018 .09
-
황련 추출물의 아토피피부염 유발 생쥐에서 피부손상 완화 효과
동의생리병리학회지
2019 .01
-
Interleukin-18 Receptor α Modulates the T Cell Response in Food Allergy
Allergy, Asthma & Immunology Research
2022 .07
-
아토피피부염의 표현형과 내재형
Allergy Asthma & Respiratory Diseases
2020 .01
-
Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8+ T Cells, Resulting in Enhanced IL-1β Dependent Effector Function
Immune Network
2021 .10
-
IL-24 Contributes to Neutrophilic Asthma in an IL-17A-Dependent Manner and Is Suppressed by IL-37
Allergy, Asthma & Immunology Research
2022 .09
-
Clinical Characteristics and Genetic Variations in Early-Onset Atopic Dermatitis Patients
Annals of Dermatology
2019 .01
-
The Serum Levels of Resistin and Its Relationship with Other Proinflammatory Cytokines in Patients with Alzheimer’s Disease
Clinical Psychopharmacology and Neuroscience
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-517-000338091