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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 629 - 640 (12page)
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초록· 키워드
오류제보하기
Objective : The purpose of this study was to investigate the neuroprotective effect of Jukryuk on 4-vessel occlusion(4-VO) and middle cerebral artery (MCA) ischemia.
Method : After administration of Jukryuk, we compared the Jukryuk-treated group, the control, and the sham groups, in view of several points as follows 1) We evaluated the damage characterized by coagulative cell change of pyramidal neurons and pronounced gliosis in each group 2) We counted the number of normal pyramidal shapes after ischemia in each group 3) Immunohistochemistry (cyclooxygenase-2) 4) In focal ischemic injury model, we measured the volume of ischemic area
Results : In this experiment, the effect of Jukryuk was determined to be protecting neuron cell shape, reducing the number of neuron cells damaged by ischemia and the volume of the ischemic area.
In immunohistochemistry, Jukryuk reduced cyclooxygenase-2 expression
Conclusions : According to this study, Jukryuk can protect neuron cells from injury by cerebrovascular ischemia
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Barone FC / 1999 / Inflammatory mediators and stroke. New opportunities for novel therapeutics / J Cereb Blood Flow Metab 19 : 819 ~ 834
Busto R / 1987 / Small differences in intraischaemic brain temperature critically determine the extent of ischeaemic neuronal injury / J Cereb Blood Flow Metab 7 : 720 ~ 738
Connolly ES Jr. / 1997 / Exacerbation of cerebral injury in mice that express the P-selectin gene : identification of P-selectin blockade as a new target for the treatment o
Costantino ladecola / 2001 / Cerebral ischemia and inflammation / Current Opinion in Neurology 14 : 89 ~ 94
Crain BJ / 1988 / Selective neuronal death after transient ischemia in the mongolian gerbil: a silver impregnation study / Neuroscience 27 : 387 ~ 402
Busto R / 1987 / Small differences in intraischaemic brain temperature critically determine the extent of ischeaemic neuronal injury / J Cereb Blood Flow Metab 7 : 720 ~ 738
Connolly ES Jr. / 1997 / Exacerbation of cerebral injury in mice that express the P-selectin gene : identification of P-selectin blockade as a new target for the treatment o
Costantino ladecola / 2001 / Cerebral ischemia and inflammation / Current Opinion in Neurology 14 : 89 ~ 94
Crain BJ / 1988 / Selective neuronal death after transient ischemia in the mongolian gerbil: a silver impregnation study / Neuroscience 27 : 387 ~ 402
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