지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,181 - 1,190 (10page)
이용수
초록· 키워드
오류제보하기
Objective: This study investigated the effect of purified medical herb extracts such as Alisma canaliculatum and Polyporus umbellatus on adipogenic differentiation of human bone marrow derived mesenchymal stromal stem cells (hBMSCs). Methods: Two different medical herb were extracted using hot distilled water. The optimal concentration of extracts were fixed at 100 ng/ml by means of cell viability and cytotoxic assay. To test the adipogenic differentiation ability of extracts, we induced the adipogenesis of hBMSCs for 21 days. At day 5, the cell was harvested to check mRNA and protein expression level of adipogenic related factors. The efficacy of lipid droplet formation was evaluated using the oil-red O staining method at days 21. Results: Two different medical herb extracts have no toxicity on hBMSCs. And two different medical herb extracts significantly decreased formation of lipid droplet compared with control groups in hBMSCs. The A. canaliculatum extract group showed the lowest mRNA and protein expression level of adipossgenic related transcription factors. This data suggests that extract of A. canaliculatum and P. umbellata decrease the adipogenic differentiation of hBMSCs. Conclusions: Our findings indicate that water-extract of A. canaliculatum and P. umbellata will be useful therapeutic reagents for prevention of obesity related disease such as diabetes, hyperlipidemia, coronary artery disease, and osteoporosis.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Martin DR / 2001 / Isolation and characterization of multipotential mesenchymal stem cells from feline bone marrow / Exp Hematol 30(8):879~886
Pittenger MF / 1999 / Multilineage potential of adult human mesenchymal stem cells / Science 284(5411):143~147
Jung HS / 2012 / Peroxisome proliferator-activated receptor gamma/singal transducers and activators of transcription 5a pathway plays a key factor in adipogenesis of human bone marrow-derived stromal cells and 3T3-L1 preadipocytes / Stem Cells Dev 21(3):465~475
Duque G / 2008 / Bone and fat connection in aging bone / Curr Opin Rheumatol 20(4):429~434
Moerman EJ / 2004 / Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells : the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways / Aging Cell 3(6):379~389
Pittenger MF / 1999 / Multilineage potential of adult human mesenchymal stem cells / Science 284(5411):143~147
Jung HS / 2012 / Peroxisome proliferator-activated receptor gamma/singal transducers and activators of transcription 5a pathway plays a key factor in adipogenesis of human bone marrow-derived stromal cells and 3T3-L1 preadipocytes / Stem Cells Dev 21(3):465~475
Duque G / 2008 / Bone and fat connection in aging bone / Curr Opin Rheumatol 20(4):429~434
Moerman EJ / 2004 / Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells : the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways / Aging Cell 3(6):379~389
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
홍화 추출물이 생쥐 골수 유래 중간엽 줄기세포의 지방분화에 미치는 영향
대한한방내과학회지
2017 .01
-
Establishment of NOAEL for intracavernous injections of human bone marrow-derived mesenchymal stem cells in rats
Investigative and Clinical Urology
2020 .01
-
An optimized herbal medicine containing Scutellaria baicalensis, Alisma canaliculatum, and Atractylodes macrocephala Koidz has a potent antiplatelet and antithrombotic activity
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Optimization of adipogenic differentiation conditions for canine adipose-derived stem cells
Journal of Veterinary Science
2021 .07
-
Cytotoxic, Anti-Inflammatory and Adipogenic Effects of Inophyllum D, Calanone, Isocordato-oblongic acid, and Morelloflavone on Cell Lines
Natural Product Sciences
2016 .06
-
Anti-adipogenic effect of Artemisia annua in diet-induced-obesity mice model
Journal of Veterinary Science
2015 .12
-
인삼 다당체의 항비만 활성 평가 및 기능성 소재 개발
대한본초학회지(본초분과학회지)
2016 .01
-
홍화, 홍화씨 추출물이 MC3T3E1 세포의 골분화 과정에 미치는 영향
대한한방내과학회지
2015 .01
-
Anti-adipogenic Effect of Extract and Fractions of Cherry (Prunus serrulata var. spontanea) stem in 3T3-L1 Adipocytes
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Decline in SESN2 Expression During Aging Shifts Mesenchymal Stem Cell Differentiation from Osteogenic to Adipogenic Lineage
International Journal of Oral Biology
2024 .09
-
MicroRNA-138 Suppresses Adipogenic Differentiation in Human Adipose Tissue-Derived Mesenchymal Stem Cells by Targeting Lipoprotein Lipase
Yonsei Medical Journal
2019 .01
-
저령 추출물의 멜라닌 생성억제 작용
Korean Journal of Acupuncture
2020 .01
-
중간엽 줄기세포를 이용한 골재생의 임상적 활용
대한정형외과학회지
2019 .12
-
Composition for the Immunity Stimulatory Activity Comprising Calystegia dahuricus (Herb.) Choisy Water Extract
대한의생명과학회지
2022 .09
-
Fermented ginseng extract, BST204, disturbs adipogenesis of mesenchymal stem cells through inhibition of S6 kinase 1 signaling
Journal of Ginseng Research
2020 .01
-
Two-dimensional material-based bionano platforms to control mesenchymal stem cell differentiation
생체재료학회지
2018 .06
-
Anti-inflammatory activity of Caesalpinia sappan extract on lipopolysaccharide-treated bone marrow cells
예방수의학회지
2018 .09
-
Enhanced differentiation of mesenchymal stromal cells by three-dimensional culture and azacitidine
Blood Research
2017 .01
-
Maintenance of Proliferation and Adipogenic Differentiation by Fibroblast Growth Factor-2 and Dexamethasone Through Expression of Hepatocyte Growth Factor in Bone Marrow-derived Mesenchymal Stem Cells
대한의생명과학회지
2016 .03
-
Bone marrow-derived stem cells contribute to regeneration of the endometrium
Clinical and experimental reproductive medicine : CERM
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0