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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 1,048 - 1,060 (13page)
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초록· 키워드
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Cirsii Japonici Herba(CJ) is a wild perennial herb found in many areas of Korea as well as China and Japan, which has been used to treat bleeding and inflammation. Silibinin is the main flavonoid extracted from milk thistle (Cirsii Japonici Herba). It exhibits potent antioxidant activity and anti-inflammatory effect. In this study, the effect of CJ and silibinin extract on lipopolysaccharide-induced inflammation was investigated using MTS assay, RT-PCR, western blot, and nitric oxide detection on mouse BV2 microglial cell lines. In the present results, CJ and silibinin extract suppressed nitric oxide production by inhibiting the lipopolysaccharide-stimulated enhancement of COX-2 and iNOS gene expression in BV2 cells.
Moreover, CJ and silibinin also repressed some lipopolysaccharide-induced signaling molecules. Importantly, catalase-induced COX-2 and iNOS expression needed activations of NF-κB, PI3K/Akt, and MAPK, which were important for the transcriptional up-regulation of COX-2 and iNOS.
CJ and silibinin interaction on BV2 cells down-regulated NF-κB-dependent proinflammatory cytokine (IL-2,IL-6) expression. They are involved in the regulation of inflammatory responses.
These data shows that CJ and silibinin exerts anti-inflammatory and analgesic effects, probably by suppression of COX-2 and iNOS synthase expression in BV2 microglial cells.
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등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Ahmed NN / 1997 / Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase / Proc Natl Acad Sci USA 94 : 3627 ~ 3632
Chao CC / 1995 / cytokines, and neurotoxicity / Crit Rev Neurobiol 9 : 189 ~ 205
Cohen HY / 2004 / Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase / Science 305 : 390 ~ 392
Crofford L. J. / 2000 / / Arthritis Rheum 43 : 4 ~ 13
Dawson T.M. / 1992 / / Ann. Neurol 32 : 297 ~ 311
Chao CC / 1995 / cytokines, and neurotoxicity / Crit Rev Neurobiol 9 : 189 ~ 205
Cohen HY / 2004 / Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase / Science 305 : 390 ~ 392
Crofford L. J. / 2000 / / Arthritis Rheum 43 : 4 ~ 13
Dawson T.M. / 1992 / / Ann. Neurol 32 : 297 ~ 311
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大薊와 실리비닌의 Mouse BV2 Microglial Cells에서 Lipopolysaccharide에 의해 유발된 염증반응에 대한 신경보호 효과
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大薊의 주성분인 Silibinin이 알레르기 염증반응에 미치는 效果
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Inhibitory Action of Minocycline on Lipopolysaccharide-Induced Release of Nitric Oxide and Prostaglandin E2 in BV2 Microglial Cells
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Effect of Ethanol Extracts from Defatted Perilla frutescens on LPS-induced Inflammation in Mouse BV2 Microglial Cells
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창출 추출물의 BV2 cell 소염작용에 관한 실험적 연구
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지질다당체유도 BV2세포손상에 대한 상백피 추출물의 항염증작용
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2010 .06
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Silibinin Induces Apoptotic Cell Death Via ROS-dependent Mitochondrial Pathway in Human Glioma Cells
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Effects of Anemarrhenae Rhizoma on LPS-stimulated Expression of COX-2 and iNOS in mouse BV2 microglial cells
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2005 .01
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오령산가온비탕의 BV2에서 LPS로 유도된 nitric oxide 및 $TNF-{\alpha}$ 생성에 미치는 영향
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Immunosuppressive Effect of Silibinin in Experimental Autoimmune Encephalomyelitis
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
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Anticancer effect of silibinin on the xenograft model using MDA-MB-468 breast cancer cells
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2014 .09
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황련 클로로포름 분획물의 뇌신경소교세포로부터 염증매개물질 생성억제 효능 연구
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2007 .01
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Comparative Evaluation of Silibinin Effects on Cell Cycling and Apoptosis in Human Breast Cancer MCF-7 and T47D Cell Lines
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Protective Effects of Silibinin and Its Possible Mechanism of Action in Mice Exposed to Chronic Unpredictable Mild Stress
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
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Effects of the Aqueous Extract of Rehmanniae Radix Preparata on Lipopolysaccharide-induced Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells
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2006 .01
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Genome Wide Expression Profile of Agrimonia pilosa in LPS-stimulated BV-2 Microglial Cells
Molecular & cellular toxicology
2009 .01
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Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2013 .01
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Genome Wide Expression Profile of Asiasarum sieboldi in LPS-stimulated BV-2 Microglial Cells
Molecular & cellular toxicology
2008 .01
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Combined treatment of silibinin with either sorafenib or EGFR tyrosine kinase inhibitors enhances growth inhibitory effects in hepatocellular carcinoma cells
Clinical and Molecular Hepatology
2015 .01
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Inhibition of Production of Reactive Oxygen Species and Gene Expression Profiles by Cirsii Japonici Herba Extract Treatment in HepG2 Cells
Molecular & cellular toxicology
2005 .01
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