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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 379 - 386 (8page)
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초록· 키워드
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Objective : Immune potentiation including activation of T cells, B cells, macrophages, and dendritic cells is known to play a key role in prevention and treatment of patients with cancer. In this study, we investigated the effects of Acanthopanax sessiliflorus (AR) on the immune system, especially on thymocytes, splenocytes, and macrophages.Methods : We investigated the effects of AR on proliferation of splenocytes in normal mice, and the effects on proliferation of splenocytes and thymocytes in tumor-bearing mice. In addition, the effect of AR on NO production using macrophages was investigated. Results : Treatment with AR accelerated proliferation of splenocytes in vitro. AR also accelerated thymocyte proliferation, but did not affect splenocytes proliferation in normal mice. In contrast, AR accelerated proliferation of splenocytes and thymocytes significantly in tumor bearing mice. In addition, NO production level from macrophages was elevated by treatment with AR.Conclusion : These results demonstrate that AR has anti-cancer activities and related mechanisms are involved in immune potentiation such as acceleration of immune cell proliferation and elevation of NO production level in macrophages. In addition, we also demonstrate the possibilities of AR as complementary and alternative medicine to standard anti-cancer drugs.
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참고문헌 (18)
참고문헌 신청
/ 1978 / A method for cell selection : 2844 ~ 48
/ 1979 / Regulation of lymphocyte-activating factor production and secretion in P388D1 cells identification of high molecular weight precursors of LAF Journal of Immunologic
/ 1982 / Analysis of nitrite and [15N] nitrate in biological fluids wish (k) : 131 ~ 6
/ 1985 / Anti-inflammatory action of ethanol extracts from Acanthopanax sessiliflorus : 37 ~ 41
/ 1985 / Immunologically activity polysaccharides of Acanthopanax senticosus : 2619 ~ 22
/ 1979 / Regulation of lymphocyte-activating factor production and secretion in P388D1 cells identification of high molecular weight precursors of LAF Journal of Immunologic
/ 1982 / Analysis of nitrite and [15N] nitrate in biological fluids wish (k) : 131 ~ 6
/ 1985 / Anti-inflammatory action of ethanol extracts from Acanthopanax sessiliflorus : 37 ~ 41
/ 1985 / Immunologically activity polysaccharides of Acanthopanax senticosus : 2619 ~ 22
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