메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한한방내과학회 대한한방내과학회지 대한한방내과학회지 제35권 제3호
발행연도
2014.1
수록면
262 - 273 (12page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

이 논문의 연구 히스토리 (2)

초록· 키워드

오류제보하기
Objectives: This study was carried out to investigate the protective effect of Coptidis Rhizoma steamed with rice wine(CR) against gastroduodenal mucosal injury through inhibiting inducible nitric oxide synthase (iNOS) activation. Methods: In in vitro experiment, LPS-induced RAW 264.7 macrophages were treated with CR(0.4, 0.6, 0.8, 1.0 mg/ml)and iNOS mRNA expression and nitric oxide (NO) production were measured. In in vivo experiment normal group mice weretreated with neither ethanol nor CR. Both control and sample group mice were orally administrated with ethanol. Five hoursafter ethanol administration control group mice were orally administrated with distilled water, sample group mice were orallyadministrated with CR. After three days administration, gastroduodenal mucosa of mice was observed histopathologically andiNOS, nuclear factor-kappa B (NF-κB) activation were observed immunohistochemically. Results: In in vitro experiment iNOS mRNA expression and NO production in LPS-induced RAW 264.7 macrophages weredecreased by CR dose-dependently. In in vivo experiment, gastroduodenal mucosal injury was repaired by CR and iNOS, NF-κBactivation in gastroduodenal mucosa were decreased by CR. Conclusions: Coptidis Rhizoma steamed with rice wine has a protective effect against gastroduodenal mucosal injury throughinhibiting iNOS activation.

목차

등록된 정보가 없습니다.

참고문헌 (29)

참고문헌 신청

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0