Epstein-Barr 바이러스 유행지역에서 두경부암 발생과의 연관성

김아영; 노종렬; 김진만; 나기상; 박찬일

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자료유형: 학술저널

저자정보: 김아영 노종렬 김진만 나기상 박찬일

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제3호

발행연도: 2007.1

수록면: 235 - 239 (5page)

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Background and Objectives：A number of reports have suggested that Epstein-Barr virus (EBV) is associated with different forms of head and neck cancers (HNC) such as nasopharyngeal carcinoma, NK/T cell lymphoma and Burkitts lymphoma. We evaluated the association of EBV with HNC as a causative factor in an endemic area of the virus. Subjects and Method：Fresh specimens of HNC were obtained from 72 new patients between August 2003 and January 2005. In situ hybridization for EBER was performed with immunohistochemical staining of p53, Bcl-2 and LMP-1 and serologic tests on anti-viral capsid antigen (VCA) and anti-early antigen (EA)-D. The results of EBV positivity were analyzed according to tumor TNM stages, sites, pathology and smoking status. A correlation between EBV positivity and p53, Bcl-2, LMP-1 positive staining was investigated. Results：Nine (12% ) of the total 72 patients showed EBV positivity of tumor, depending mainly on pathology and sites, but not tumor staging, age, sex or smoking status：NPC (3), NK/T cell lymphoma (5), lymphoephithelial carcinoma of the parotid gland (1). All patients had sero-positivity of anti-VCA IgG but not anti-VCA IgM and anti-EA-D. There was a relationship between the presence of EBV, its oncoprotein (LMP-1) and oncogene (Bcl-2). Conclusion：Overall, the incidence of EBV positivity of HNC in an endemic area is not significantly different from the prior reports about non-endemic area. The associa-tion between EBV and LMP-1 or Bcl-2 may be helpful for understanding the role of viral oncogenes in the HNC. (Korean J Otolaryngol 2007 ;50 :235-9)

#Epstein-Bar 바이러스·두경부암·제자리부합법·원인자·유행지역. #Epstein-Barr virus #EBV)· Head and Neck cancer· In situ hybridization· Causative factor· Endemic area.

참고문헌 (20)

참고문헌 신청

/ / Induction of bcl-2 expression by Epstein-Barrvirus latent membrane protein 1 protects infected B cells from programmedcell death : 1107 ~ 15

/ / a viral homologue of Bcl-2 protects human B cells from programmed cell death : 8479 ~ 83

/ 2001 / Detection rates of Epstein-Barr virus from the chronic tonsillitis and its typing 44 : 1171 ~ 1176

/ jclinmicrobiol1993 / Detectionof Epstein-Barr virus and human papillomavirus in head and necktumors : 53 ~ 6

/ jclinmicrobiol1994 / Prevalence of Taiwanvariant of Epstein-Barr virus in throat washings from patients withhead and neck tumors in Taiwan : 28 ~ 31

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