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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 868 - 871 (4page)
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초록· 키워드
오류제보하기
Background and Objectives：T helper-type 2 cytokines, such as IL-4 and IL-13, may play a central role in allergic diseases. The proteins known as signal transducers and activators of transcription 6 (STAT-6) are key transcription factors involved in both IL-4 and IL-13 mediated biological responses. Since a polymorphism of STAT6 G2964A has been found, we investigated Subjects and Method：Blood samples for genetic analysis were obtained from 229 individuals with allergic rhinitis and from 278 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for the STAT6 G2964A variant was used for genotyping. Results：There were no diferences in the frequencies of the genotypes bn etweethe controls and patients (p>0.05). The frequencies of the STAT6 2964A allele were not statisticaly diferent between controls and alergic rhinitis patients (p> ). Conclusion：Our result sugests that the STAT6 G2964A polymorphism might not give susceptibility to the development of allergic rhinitis in Koreans.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
/ / Variants of STAT6(signal transducer and activator of transcription
/ 1919 / Human sensitization 1 : 201 ~ 205
/ 1988 / A simple salting out procedurefor extracting DNA from human nucleated cells 16 : 1215 ~
/ 1988 / Dominant inheritance of atopic immunoglobulin-E responsiveness 1 : 86 ~ 88
/ 1994 / Evidence for Mendelian inheritance of serum IgE levelsin Hispanic and non-Hispanic white families 55 : 555 ~ 565
/ 1919 / Human sensitization 1 : 201 ~ 205
/ 1988 / A simple salting out procedurefor extracting DNA from human nucleated cells 16 : 1215 ~
/ 1988 / Dominant inheritance of atopic immunoglobulin-E responsiveness 1 : 86 ~ 88
/ 1994 / Evidence for Mendelian inheritance of serum IgE levelsin Hispanic and non-Hispanic white families 55 : 555 ~ 565
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(E)-2,4-Bis(p-hydroxyphenyl)-2-butenal enhanced TRAIL-induced apoptosis in ovarian cancer cells through downregulation of NF-${\kappa}B$/STAT3 pathway
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