Tumor Necrosis Factor 유전자 다형성을 이용한한국인 알레르기비염환자에서의 감수성에 대한 연구

이재훈; 최태욱; 정하민; 김정중; 이정헌; 민정열

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자료유형: 학술저널

저자정보: 이재훈 최태욱 정하민 김정중 이정헌 민정열

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제9호

발행연도: 2005.1

수록면: 1,107 - 1,110 (4page)

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Background and Objectives：Tumor necrosis factor-α (TNF-α) is recognized as a proinflammatory host alert cytokine that is synthesized early during inflammation, and elevations of this cytokine have been reported in patients with allergic rhinitis. The TNF-α gene is located on chromosome 6p within the class III region of the major histocompatibility complex. The most widely studied polymorphism within the TNF-α gene involves a guanine (G)/adenine (A) substitution at position -308. We therefore tested whether TNF-α -308G/A polymorphism are associated with allergic rhinitis in a Korean population. Subjects and Method：Blood samples for genetic analysis were obtained from 191 individuals with allergic rhinitis and from 192 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for TNF-α -308G/A was used for genotyping. Serum total IgE levels were determined by using the immunoassay. Eosinophil values were determined by eosinophil numbers per total cell numbers per μl. Results：There were no differences in the frequencies of the genotypes and alleles of TNF-α -308G/A in the controls and patients(p>0.05). Blood eosinophil count and total serum IgE levels were not statistically different in the genotypes of TNF-α -308G/A in allergic rhinitis(p>0.05). Conclusion：We thought that the TNF-α -308G/A polymorphism is unlikely to be an important marker for predisposition to allergic rhinitis. A further study involving a larger Korean population might be in need.

#Tumor necrosis factor-alpha·알레르기비염·한국인·유전자 다형성. #Tumor necrosis factor-alpha·Allergic rhinitis·Korean·Polymorphism.

참고문헌 (20)

참고문헌 신청

/ / genedetectable by Ncol restriction of PCR product

/ 1988 / A simple salting out procedure forextracting DNA from human nucleated cells 16 : 1215 ~

/ 1993 / No independent associationbetween a tumour necrosis factor alpha promoter polymorphismand insulin-dependent diabetes mellitus 23 : 3050 ~ 3

/ 1996 / Gene polymorphism at position -308 of the tumor-necrosis-factor- α in multiple sclerosis and its influence on the regulation ofTNF-α production : 75 ~ 8

/ 1996 / Polymorphism at the tumour necrosis factor locus andasthma 33 : 125 ~ 37

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소속기관 원광대학교 의과대학 이비인후과학교실

주요연구분야 의약학 > 의학 일반 의약학 > 임상의학 > 이비인후과학

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