편측 갑상선 절제술 후의 갑상선 기능저하증에 대한 임상적, 병리학적 고찰

고윤우; 이승원; 이용만; 김효진; 이종대; 목지오; 변동원; 김희경

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자료유형: 학술저널

저자정보: 고윤우 이승원 이용만 김효진 이종대 목지오 변동원 김희경

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제5호

발행연도: 2006.1

수록면: 532 - 537 (6page)

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연구배경

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연구결과

이 논문의 연구 히스토리 (3)

2008

국소마취하의 갑상선절제술에 대한 예비결과

고윤우 , 이준호 , 이승원 외 1명 대한두경부종양학회 학술대회 2008.01 학술대회자료

2006

완성형 갑상선절제술의 안전성에 대한 고찰：예방적 절제술군과치료적 절제술군에 대한 비교연구

고윤우 , 이승원 , 김효진 외 5명 대한이비인후-두경부외과학회지 2006.01 학술저널

편측 갑상선 절제술 후의 갑상선 기능저하증에 대한 임상적, 병리학적 고찰

고윤우 , 이승원 , 이용만 외 5명 대한이비인후-두경부외과학회지 2006.01 학술저널

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Background and Objectives：In hemithyroidectomy, most surgeons don’t care about postoperative hypothyroidism because ofthe remaining functioning contralateral thyroid lobe, but the incidence of hypothyroidism after hemithyroidectomy is reported from5 to 35%. The purpose of this study was to assess the incidence, natural history, factors contributing to hypothyroidism after hemithyroidectomy.Subjects and Method：212 consecutive cases of hemithyroidectomized patients diagnosed from Feb. 2001 throughDec. 2004 were retrospectively analyzed. One hundred thirty-six of 212 cases were enrolled in this study after the exclusion criteriaapplied. The definition of postoperative hypothyroidism was based on serum TSH and free T4 level. The relationship betweenhypothyroidism and several factors, such as mean age, sex, preoperative free T4, TSH, microsomal antibody, thyroglobulin antibodylevels and lymphocytic infiltration of the resected gland, were stastically analyzed. Results：The fifty eight of 136 patients(42.6%) became biochemical hypothyroidism postoperatively. Among them, 11 patients (8.1%) showed overt hypothyroidismand 47 patients (34.5%) showed subclinical hypothyroidism. In postoperative hypothyroid group, preoperative TSH, microsomaland thyroglobulin Ab levels and lymphocytic infiltration were significantly higher than in postoperative euthyroid group (p<0.05).The odds ratio of preoperative microsomal Ab, thyroglobulin Ab level and lymphocytic infiltration of resected gland was 17.18,3.01 and 2.26 folds, respectively. Conclusion：In this study, we confirmed that there was unexpectedly high incidence of postoperativehypothyroidism after hemithyroidectomy. We propose that preoperative high TSH level, positive microsomal Ab, thyroglobulinAb and marked lymphocytic infiltration of resected gland could be predicitive factors of postoperative hypothyroidismafter hemithyroidectomy. (Korean J Otolaryngol 2006;49:532-7)

#갑상선 기능저하증·갑상선절제술. #Hypothyroidism·Thyroidectomy.

참고문헌 (16)

참고문헌 신청

/ 1960 / The relation of thyroidauto-immunity to round-celled infiltration of the thyroid gland 13 : 499 ~ 501

/ 1962 / The prognostic significance ofthyroid antibodies in the management of thyrotoxicosis 2 : 843 ~ 7

/ 1981 / The pituitary-thyroid axis after hemithyroidectomy in euthyroidman 53 : 377 ~ 80

/ 1983 / Study of the pituitary-thyroid axis in euthyroid goiter after partial thyroidectomy 6 : 485 ~ 7

/ 1985 / Thyroid function after resection for non-toxic goitre with specialreference to thyroid lymphocytic aggregation and circulatingthyroid autoantibodies acta endocri (l)

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