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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제8권 제4호
- 발행연도
- 2015.1
- 수록면
- 385 - 389 (5page)
이용수
초록· 키워드
오류제보하기
Objectives. The aim of this study was to evaluate the component-resolved diagnosis using a microarray allergen chip (Immuno Solid-phase Allergen Chip, ImmunoCAP ISAC) and to compare this new diagnostic tool with the established ImmunoCAP methods for allergen-specific IgE detection in allergic rhinitis patients. Methods. One hundred sixty-eight allergic rhinitis patients were included in this study. All the patients were diagnosed with allergic rhinitis according to their clinical symptoms, physical examination and a positive skin prick test. We analyzed their specific IgEs for house dust mites (Dermatophagoides farine [DF] and Dermatophagoides pteronyssinus [DP]), Alternaria alternata, birch, and mugwort using ImmunoCAP and ImmunoCAP ISAC in the same patient sample. We compared the sensitivity and correlation between the two tests. Results. In cases of allergies to DP and DF, the sensitivity of the specific IgE was 80% and that of the allergen microarray was 78.9%. The correlation between the two tests was significant for both DP and DF (P<0.001). For the A. alternata, birch and mugwort allergens, the sensitivity of ImmunoCAP ISAC was slightly lower than that of ImmunoCAP. Conclusion. These results suggest that the allergen microarray chip method is a reliable new method to diagnose the components of an allergen in patients with allergic rhinitis sensitive to house dust mites. Further study about the utility of the allergen microarray is needed.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bousquet J / 1994 / Specific immunotherapy in asthma / Allergy Proc 15 (6) : 329 ~ 333
Bronnert M / 2012 / Component-resolved diagnosis with commercially available D. pteronyssinus Der p 1, Der p 2 and Der p 10: relevant markers for house dust mite allergy / C
Cabrera-Freitag P / 2011 / Can component-based microarray replace fluorescent enzimoimmunoassay in the diagnosis of grass and cypress pollen allergy? / Clin Exp Allergy 41 (
Canonica GW / 2013 / A WAO - ARIA - GA²LEN consensus document on molecular-based allergy diagnostics / World Allergy Organ J 6 (1) : 17 ~
Cerecedo I / 2008 / Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay / J Allergy Clin Immunol 122 (3) : 589 ~ 594
Bronnert M / 2012 / Component-resolved diagnosis with commercially available D. pteronyssinus Der p 1, Der p 2 and Der p 10: relevant markers for house dust mite allergy / C
Cabrera-Freitag P / 2011 / Can component-based microarray replace fluorescent enzimoimmunoassay in the diagnosis of grass and cypress pollen allergy? / Clin Exp Allergy 41 (
Canonica GW / 2013 / A WAO - ARIA - GA²LEN consensus document on molecular-based allergy diagnostics / World Allergy Organ J 6 (1) : 17 ~
Cerecedo I / 2008 / Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay / J Allergy Clin Immunol 122 (3) : 589 ~ 594
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