Decreased Serum Epinephrine in Children With Positive Skin Prick Test

조재훈; 김진국; 김인태; Jeffrey D. Suh; 오정인; 홍석찬; 최지호; 정소정; 이승훈

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자료유형: 학술저널

저자정보: 조재훈 김진국 김인태 Jeffrey D. Suh 오정인 홍석찬 최지호 정소정 이승훈

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제8권 제4호

발행연도: 2015.1

수록면: 381 - 384 (4page)

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Objectives. To evaluate the association between catecholamine levels and skin prick test results among children. Methods. Two hundred eight first grade children from one elementary school were invited to participate in this study. Skin prick test (SPT) for six allergens (2 house dust mites, cat, dog, mugwort, and pollen mixture) was performed, and patient demographic information was recorded. The parents were surveyed using questionnaires about rhinitis-related symptoms. Finally, venous blood sampling was done to measure catecholamine levels (epinephrine, norepinephrine, and dopamine) by high-performance liquid chromatography. Results. Out of 208 children, 174 (106 boys and 68 girls) enrolled in this study. Ninety-six of the children (55%) had negative SPT (nonsensitization group), while 78 (45%) had a positive SPT to at least one of six allergens (sensitization group). The diagnosis of chronic rhinitis was more prevalent in the sensitization group (35.9%) than nonsensitization group (26.0%), however the finding was not significant (P=0.186). Epinephrine levels were decreased between the sensitization group compared to the nonsensitization group (P=0.004). There was no difference in norepinephrine and dopamine levels (P>0.05). Conclusion. Epinephrine levels are lower in children with positive SPT compared to controls, however, the level of the catecholamine was not associated with the presence or absence of rhinitis symptoms.

#Allergic Rhinitis #Epinephrine #Child #Skin Tests

참고문헌 (12)

참고문헌 신청

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조재훈

소속기관 Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University School of Medicine, Seoul, Korea