125I Seed Permanent Implantation as a Palliative Treatment for Stage III and IV Hypopharyngeal Carcinoma

Lei Li; Jie Yang; Xiaojiang Li; Xiaoli Wang; Yanxin Ren; Jimin Fei; Yan Xi; Ruimei Sun; Jing Ma

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자료유형: 학술저널

저자정보: Lei Li Jie Yang Xiaojiang Li Xiaoli Wang Yanxin Ren Jimin Fei Yan Xi Ruimei Sun Jing Ma

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제9권 제3호

발행연도: 2016.1

수록면: 185 - 191 (7page)

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Objectives. The aim of this study was to investigate the feasibility and safety of percutaneous 125I seed permanent implantation for advanced hypopharyngeal carcinoma from toxicity, tumor response, and short-term outcome. Methods. 125I seeds implant procedures were performed under computed tomography for 34 patients with advanced hypopharyngeal carcinoma. We observed the local control rate, overall survival, and acute or late toxicity rate. Results. In the 34 patients (stage III, n=6; stage IV, n=28), the sites of origin were pyriform sinus (n=29) and postcricoid area (n=5). All patients also received one to four cycles of chemotherapy after seed implantation. The post-plan showed that the actuarial D90 of 125I seeds ranged from 90 to 158 Gy (median, 127 Gy). The mean follow-up was 12.3 months (range, 3.4 to 43.2 months). The local control was 2.1–31.0 months with a median of 17.7 months (95% confidence interval [CI], 13.4 to 22.0 months). The 1-, 2-, and 3-year local controls were 65.3%, 28.6%, and 9.5% respectively. Twelve patients (35%) died of local recurrence, fourteen patients (41%) died of distant metastases, and three patients (9%) died of recurrence and metastases at the same time. Five patients (15%) still survived to follow-up. At the time of analysis, the median survival time was 12.5 months (95% CI, 9.5 to 15.4 months). The 1-, 2-, and 3-year overall survival rates were 55.2%, 20.3%, and 10.9%, respectively. Five patients (15%) experienced grade 3 toxic events and nine patients (26%) have experienced grade 2 toxic events. Conclusion. This review shows relatively low toxicity for interstitial 125I seed implantation in the patients with advanced stage hypopharyngeal cancer. The high local control results suggest that 125I seed brachytherapy implant as a salvage or palliative treatment for advanced hypopharyngeal carcinoma merit further investigation.

#Keywords. Hypopharyngeal neoplasms #Brachytherapy #Palliative care

참고문헌 (14)

참고문헌 신청

Godballe C. / 2002 / Hypopharyngeal cancer : results of treatment based on radiation therapy and salvage surgery / Laryngoscope 112(5):834~838

MacKenzie RG. / 2000 / Comparing treatment outcomes of radiotherapy and surgery in locally advanced carcinoma of the larynx : a comparison limited to patients eligible for surgery / Int J Radiat Oncol Biol Phys 47(1):65~71

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