백서 코점막에서 발육에 따른 백혈구형 12-Lipoxygenase의 발현

이윤재; 윤주헌; 이주환; 전희선; 김경수; 박태준

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자료유형: 학술저널

저자정보: 이윤재 윤주헌 이주환 전희선 김경수 박태준

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제1호

발행연도: 2005.1

수록면: 40 - 45 (6page)

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Background and Objectives：We determined the localization of leukocyte-type 12-lipoxygenase (L-12-LO) in murine nasal mucosa and to investigate the expression of L-12-LO according to the development of murine nasal mucosa. Materials and Method：Immunohistochemical staining was done on the nasal mucosa of mice at gestational days 16, 17, 18, and mice at postnatal days 1, 3, 7, 14, and adult mice. Alcian blue (pH 2.5)-periodic acid Schiff staining on murine nasal mucosa was performed. Results：In murine nasal respiratory mucosa, the expression of L-12-LO was noted in ciliated epithelial cells, basal cells, serous acini, and secretory ducts, but it was not found in the mucous acini and goblet cells. In olfactory mucosa, the expression of L-12-LO was noted in the olfactory receptor cells, supporting cells, and basal cells. The expression in respiratory mucosa according to the development was strongly noticed from the gestational day 16 through postnatal day 7. The expression in postnatal day 14 and adult mice was weaker than in the previous time point. The expression in olfactory mucosa showed no difference throughout the developmental stage. Conclusion：As a result of this study, we found the exact localization of L-12-LO in murine nasal mucosa, and we also found the different expression of L-12-LO between the respiratory and olfactory mucosa. This fact suggests the possible involvement of L-12-LO in the development of murine respiratory mucosa.

#12-Lipoxygenase·비점막·발달·조직화학염색. #Arachidonate 12-lipoxygenase·Nasal mucosa·Development·Immunohistochemistry.

참고문헌 (19)

참고문헌 신청

/ / -hydroxyeicosatetraenoic acid is the major arachido-nic acid metabolite in human bronchi Asociation with airway epi-thelium : 254 ~ 62

/ / mutagenesis of C-teminal isoleucine and chromosomal localizations of murine 12-lipoxygenase ge (mic structure) : 13979 ~ 87

/ 198 / Meta-bolism of arachidonic acid by human nasal and bronchial epithelial cells 267 : 426 ~ 36

/ 1988 / Two imunologicaly and cata-lytically distinct arachidonate 12-lipoxygenases of bovine platelets and leukocytes 266 : 613 ~ 21

/ 1991 / Cloning and expresion of arachidonate 12-lipoxygenase cDNA from porcine leukocytes 21a : 29 ~ 32

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