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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제10권 제3호
- 발행연도
- 2017.1
- 수록면
- 241 - 247 (7page)
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초록· 키워드
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Objectives. This case-controlled study aimed to identify the association of tumor necrosis factor (TNF)α-1031 and TNFβ+ 252 gene polymorphisms between chronic rhinosinusitis (CRS) and healthy controls. Another purpose of this study was to investigate the associations of these gene polymorphisms with factors related to CRS.
Methods. All deoxyribonucleic acid (DNA) samples were genotyped for TNFα-1031 and TNFβ+252 genes by mean of polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP). The statistical analysis were carried out using chi-square test or Fisher exact test to determine the associations of these gene polymorphisms in CRS. Multiple logistic regression was performed to evaluate the associations of these gene polymorphisms in CRS and its related risk factors.
Results. The genotype and allele frequencies of TNFα-1031 and TNFβ+252 gene did not show any significant associations between CRS and healthy controls. However, a significantly statistical difference of TNFα-1031 was observed in CRS participants with atopy (P-value, 0.045; odds ratio, 3.66) but not in CRS with asthma or aspirin intolerance.
Conclusion. Although the presence of TNFα-1031 and TNFβ+252 gene polymorphisms did not render any significant associations between CRS and healthy control, this study suggests that TNFα-1031 gene polymorphisms in CRS patients with atopy may be associated with increase susceptibility towards CRS.
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참고문헌 (31)
참고문헌 신청
Mfuna Endam L / 2010 / Association of IL1A, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: a replication study / Arch Otolaryngol Head Neck Surg 136(2):187~192
Szabo K / 2013 / The -308 G>A SNP of TNFA is a factor predisposing to chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarian individuals: conclusions of a genetic study with multiple stratifications / Int Immunol 25(6):383~388
Berghea EC / 2014 / Association of TNF-alpha gene polymorphism with nasal polyposis in Romanian asthmatic patients / Rom J Rhinol 4(15):149~155
Bohonak AJ. / 2008 / Encyclopedia of life sciences / John Wiley & Son
Pawankar R / 2007 / Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps / Curr Allergy Asthma Rep 7(3):202~208
Szabo K / 2013 / The -308 G>A SNP of TNFA is a factor predisposing to chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarian individuals: conclusions of a genetic study with multiple stratifications / Int Immunol 25(6):383~388
Berghea EC / 2014 / Association of TNF-alpha gene polymorphism with nasal polyposis in Romanian asthmatic patients / Rom J Rhinol 4(15):149~155
Bohonak AJ. / 2008 / Encyclopedia of life sciences / John Wiley & Son
Pawankar R / 2007 / Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps / Curr Allergy Asthma Rep 7(3):202~208
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