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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 391 - 399 (9page)
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Purpose: Inflammatory cytokines are thought to be involved in the pathogenesis of intracranial aneurysm (IA), although results among studies in the literature are inconsistent. This article sought to review studies on the associations among polymorphisms in inflammatory cytokine genes and IA risk and to provide recommendations for future research. Materials and Methods: A systematic search of PubMed, Embase, and Web of Science was conducted up to August 4, 2019. The associations between polymorphisms of inflammatory cytokine genes and IA risk were estimated by pooled odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses were performed according to race. Qualitative systematic review was conducted for variants that were studied in only one study. All analyses were performed using STATA 12.0. Results: 13 studies investigating the associations between polymorphisms in five inflammatory cytokine genes (TNF-α, IL-1α, IL-1β, IL6, and IL-12B) and IA were reviewed. Combined results showed that the A allele of TNF-α rs1800629 polymorphism has a protective effect against IA (dominant model: OR=0.65, 95% CI=0.47–0.89, p=0.007). No associations were identified between polymorphisms in IL-1α rs1800587, IL-1β rs16944, IL6 rs1800795 and rs1800796, or IL-12B rs3212227 and IA risk. Conclusion: This review demonstrated an association between TNF-α rs1800629 polymorphism and IA in Caucasians, illustrating the potentially important role of genes involved in inflammation in IA.
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참고문헌 (40)
참고문헌 신청
Brown RD Jr / 2014 / Unruptured intracranial aneurysms : epidemiology, natural history, management options, and familial screening / Lancet Neurol 13:393~404
Zhou S / 2018 / Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population / Sci Rep 8:4356
Liu H / 2016 / Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population / BMC Neurol 16:14
Connolly ES Jr / 2001 / Influence of smoking, hypertension, and sex on the phenotypic expression of familial intracranial aneurysms in siblings / Neurosurgery 48:64~68
Caranci F / 2013 / Epidemiology and genetics of intracranial aneurysms / Eur J Radiol 82:1598~1605
Zhou S / 2018 / Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population / Sci Rep 8:4356
Liu H / 2016 / Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population / BMC Neurol 16:14
Connolly ES Jr / 2001 / Influence of smoking, hypertension, and sex on the phenotypic expression of familial intracranial aneurysms in siblings / Neurosurgery 48:64~68
Caranci F / 2013 / Epidemiology and genetics of intracranial aneurysms / Eur J Radiol 82:1598~1605
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